(1) Individual Fellowship: Molecular mechanisms of breast tumor metastasis; Identification of a Melonoma Susceptibilty Gene at 1p22; (2) Institutional Training: Training In Radiation Oncology Sciences; Program for Training in Cancer Epidemiology; (3) Cancer Education: Oncology Nursing Education in End of Life Care; Simultaneous Care: Linking Palliation to Clinical Trials; (4) Career: Community-based Skin Cancer Prevention Research; Prostate Cancer--Mechanisms of Bax induced Cell Death.
The Department of Health and Human Services is the Federal government's principal agency for protecting the health of all Americans and providing essential human services, especially to those who are least able to help themselves.
In FY 2007, 232 Individual FTTPs (Full Time Training Position) positions/awards were made totaling (competing and non-competing) $3,820,000; 1,213 Institutional FTTPs were supported through awards (competing and non-competing) totaling $13,906,000; 525 Career awards were made totaling $79,595,000; 89 Cancer Education awards were made totaling $31,337,000. In FY 2008, it is estimated that 1,052 Manpower awards will be made. In FY 2009, it is estimated that 2,099 Manpower awards will made. During this period, the NCI has been implementing a new strategic plan that places greater emphasis on protecting the time and stabilizing the careers of MD's in research and prevention and control scientists; nearly all of the growth in the program has focused on these two fields. Both of these fields are threatened by either managed care medicine or academic culture and they are both critical to the translational research success of the NCI in the future.
Uses and Use Restrictions
The Research Manpower program provides support for research training in all scientific fields related to cancer.
The Ruth L.
Kirschstein National Research Service Awards (NRSA) for Individual Fellows, are made directly to individuals for research training in biomedical sciences areas.
In addition, the National Institutes of Health (NIH) will award the Ruth L.
Kirschstein NRSA Institutional Research Training grants to institutions, to enable them to make NRSA awards to individuals selected by them.
Each individual who receives a postdoctoral NRSA is obligated, upon termination of the award, to comply with certain service and payback provisions.
Cancer Education Grants are designed to promote education programs carried out by organizations engaged in health-related education, research, or training, located in the United States, its possessions, or territories.
Various Career awards are designed to sponsor the development of independent scientists.
Individual short-term support for students is available under the Cancer Education Program.
University, college, hospital, public agency, or nonprofit research institution for institutional grants and individuals for fellowships.
The applicant institution must be able to provide the staff and facilities and be responsible for the selection of trainees and overall direction of the training.
Selected awardees must be citizens of the United States or be admitted to the United States for permanent residency.
Career and Cancer Education awards may be given to for-profit institutions.
University, college, hospital, public agency, nonprofit research institution or for-profit institution.
(1) Individual Ruth L. Kirschstein NRSAs: The applicant's academic record, research experience, citizenship, institutional sponsorship, and the proposed area and plan of training must be included in the application. (2) Institutional Ruth L. Kirschstein NRSAs: Applicants must show the objectives, methodology, and resources for the training program, the qualifications and experience of directing staff, the criteria to be used in selecting individuals for award and a detailed budget and justification for the amount of grant funds requested. (3) Institutional Cancer Education Grants: Applicants must describe the organization and administration of the proposed program, list and define institutional objectives, methodology, resources and techniques of evaluation, as well as a justification of proposed expenditures. (4) For Career awards, the applicant must provide documentation on the candidate, sponsor, career development plan, research proposed, and institutional commitment.
Aplication and Award Process
This program is excluded from coverage under E.O.
Applications for the Individual Ruth L. Kirschstein NRSA must be prepared using the PHS 416-1 application form and instructions for Individual National Research Service Award Fellowships (rev. 10/05). The PHS 416-1 is available at http://grants.nih.gov/grants/funding/416/phs416.htm. For further assistance, direct inquiries may be made to GrantsInfo@nih.gov or (301) 435-0714. Applications for the Institutional Ruth L. Kirschstein NRSA must be prepared using the PHS 398 Form (Revised 9/2004). Refer to Section IV of the instructions titled Instructions For Preparing An NRSA Application. The PHS 398 Form (Revised 9/2004) is available at http://grants.nih.gov/grants/funding/phs398/phs398.html. Applications for Cancer Education and Career grants must be prepared using the PHS 398 Form (Revised 9/2004). Refer to Section III of the instructions, Preparing An Individual CDA Application. Applicants are advised to consult the "Submitting an Application" section of the Program Announcement, since each award has distinct application criteria. Completed applications should be submitted to the Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 1040, Bethesda, Maryland 20892-7710 (Bethesda, MD 20817 for express/courier service).
Applications are reviewed for scientific merit by an appropriate study section, committee, or advisory council. If recommended for approval and a decision to make award is made, a formal award notice will be sent to the applicant.
All new and renewal applications: Individual NRSA's: April 8, August 8, and December 8. Institutional NRSA's: January 25, May 25, and September 25. All new, renewal, amended and supplemental Cancer Education: January 25, May 25, and September 25. All new Career applications: February 12, June 12, and October 12. All renewal, amended and supplemental Career applications: March 12, July 12, and November 12.
Public Health Service Act, Sections 413 and 487, as amended, Public Law 100-607, 42 U.S.C. 285a, 42 U.S.C. 288.
Range of Approval/Disapproval Time
Approximately 10 months.
A principal investigator (P.I.) may question the substantive or procedural aspects of the review of his/her application by communicating with the staff of the Institute. A description of the NIH Peer Review Appeal procedures is available under the Review Criteria section of the NIH Office of Extramural Research website at http://grants2.nih.gov/grants/policy/nihgps_2003/NIHGPS_Part3.htm.
Cancer Education Grants may be made for periods of up to 5 years and renewals may be submitted when appropriate. Research training grants may be renewed for additional project periods of 5 years. Only the following Career awards are renewable: K05 and K24 only a one-time renewal after a 5-year project period, and the K12 up to 5 years (Trainees 2-7 years).
Formula and Matching Requirements
Length and Time Phasing of Assistance
Up to 5 years.
Post Assistance Requirements
Progress reports are required each year.
An annual financial status report is required 90 days after the end of the budget period.
Special reports may be requested by the grantor.
Terminal reports are required 6 months after the end of a project.
"In accordance with the provisions of OMB Circular No. A-133 (Revised, June 24, 1997), Audits of States, Local Governments, and Nonprofit Organizations, nonfederal entities that expend financial assistance of $300,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Nonfederal entities that expend less than $300,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in Circular No. A-133." In addition, grants and cooperative agreements are subject to inspection and audits by DHHS and other Federal government officials.
Expenditures and other financial records must be retained for 3 years from the day on which the grantee submits the last financial status report for the report period.
(Grants/Manpower) FY 07 $179,155,000; FY 08 est $180,965,000; and FY 09 est $181,540,000.
Range and Average of Financial Assistance
$12,607 to $1,068,450; $176,160.
Regulations, Guidelines, and Literature
42 CFR 6; 42 CFR 66; 45 CFR 74; Application kit, National Institutes of Health; PHS Grants Policy Statement, DHHS Publication No. (OASH) 94-50,000, (Rev.) April 1, 1994.
Regional or Local Office
Program Contact: Dr. Lester Gorelic, Cancer Training Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6116 Executive Boulevard, Room 7025, Bethesda, MD 20892. Telephone: (301) 496-8580. Grants Management Contact: Leo F. Buscher, Jr., Grants Management Officer, National Cancer Institute, National Institutes of Health, Public Health Service, Department of Health and Human Services, EPS-234, Bethesda, MD 20892. Telephone: (301) 496-7753. Use the same numbers for FTS.
Criteria for Selecting Proposals
The major elements in evaluating proposals include the assessment of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives.