Global AIDS

The U.S.

President's Emergency Plan for AIDS Relief (PEPFAR) is the U.S.

Government initiative to help save the lives of those suffering from HIV/AIDS around the world.

This historic commitment is the largest by any nation to combat a single disease internationally, and PEPFAR investments

credit: Run Luau Run
also help alleviate suffering from other diseases across the global health spectrum.

PEPFAR is the cornerstone and largest component of the U.S.

President?s Global Health Initiative.

With a special focus on improving the health of women, newborns and children, the Global Health Initiative?s goal is to save the greatest number of lives by increasing and building upon what works and, then, supporting countries as they work to improve the health of their own people.

Agency - Department of Health and Human Services

The Department of Health and Human Services is the Federal government's principal agency for protecting the health of all Americans and providing essential human services, especially to those who are least able to help themselves.

Office - See Regional Agency Offices.

Jamie Legier, Branch Chief, International Branch, (770)488-2613, 2920 Brandywine Road, Atlanta, GA 30341.
Website Address

Relevant Nonprofit Program Categories


Selected Recipients for this Program

RecipientAmount Start DateEnd Date
Tigray Regional Health Bureau $ 2,125,000   2018-09-302023-09-29
National Alliance Of State $ 2,377,650   2017-09-302022-09-29
University Of Maryland $ 6,233,347   2017-04-012022-09-29
University Of Washington $ 26,037,958   2017-04-012022-09-29
University Of Nairobi $ 27,915,883   2017-04-012022-09-29
Centre For Health Solutions $ 19,629,974   2017-04-012022-09-29
Mkomani Clinic Society $ 24,907,106   2016-09-302022-09-29
Eastern Deanery Aids Relief Program $ 37,879,754   2016-09-302022-09-29
Coptic Orthodox Church $ 20,834,417   2016-09-302022-09-29
Elizabeth Glaser Pediatric Aids Foundation $ 75,041,323   2016-09-302022-09-29

Program Accomplishments

Not Applicable.

Uses and Use Restrictions

Uses and Restrictions are specified in individual Funding Opportunity Announcements.

Funds may be spent for reasonable program purposes, including personnel, travel, operating costs including supplies, fuel for transportation, utilities, staff training costs including registration fees and purchase and rental of training related equipment, renovation of clinical or lab facilities; and purchase of HIV testing reagents, test kits and laboratory equipment for HIV testing and services.

Equipment may be purchased if deemed necessary to accomplish program objectives; however, prior approval by CDC officials must be requested in writing.

All requests for funds contained in the budget shall be stated in U. S. dollars.

Once an award is made, CDC will not compensate foreign grantees for currency exchange fluctuations through the issuance of supplemental awards.

The costs that are generally allowable in grants to domestic organizations are allowable to foreign institutions and international organizations, with the following exception: With the exception of the American University, Beirut, and the World Health Organization (WHO), Indirect Costs will not be paid (either directly or through sub-award) to organizations located outside the territorial limits of the United States or to international organizations regardless of their location.

The applicant may contract with other organizations under this program; however the applicant must perform a substantial portion of the activities (including program management and operations, and delivery of prevention services for which funds are required).

You must obtain an annual audit of these CDC funds (program-specific audit) by a U. S. - based audit firm with international branches and current licensure/authority in-country, and in accordance with International Accounting Standards or equivalent standard(s) approved in writing by CDC.

A fiscal Recipient Capability Assessment may be required, prior to or post award, in order to review the applicant's business management and fiscal capabilities regarding the handling of U. S. Federal funds.

Please see the specific Funding Opportunity Announcement.

Eligibility Requirements

Applicant Eligibility

Competition is open, limited, or single eligibility by authorizing legislation.

Beneficiary Eligibility

This is only for non-research and research activities supported by CDC/ATSDR. For the definition of research, please see the CDC website at the following Internet address:


Requirements for application are stated in each Funding Opportunity Announcement. 2 CFR 200, Subpart E - Cost Principles applies to this program.

Aplication and Award Process

Preapplication Coordination

Preapplication coordination is not applicable.

Environmental impact information is not required for this program.

This program is excluded from coverage under E.O.


Application Procedures

2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. As specified in the Funding Opportunity Announcement

Award Procedures

As specified in the Funding Opportunity Announcement.


Contact the headquarters or regional office, as appropriate, for application deadlines.


Sections 307 and 317(k)(2), Public Health Service Act, 42 U.S.C. 242I and 247b(k)(2) as amended; Public Law 108-25, the United States Leadership Against HIV/AIDS, Tuberculosis and Malaria Act of 2003 Public Law 110-293, the Tom Lantos and Henry J. Hyde United States Global Leadership Against HIV/AIDS, Tuberculosis, and Malaria Reauthorization Act of 2008, 22 U.S.C 7601; and Public Law 113-56 PEPFAR Stewardship and Oversight Act of 2013 (P.L. 113-56). , Public Law 108-25, 22 U.S.C 7601.

Range of Approval/Disapproval Time

As specified in the Funding Opportunity Announcement.


Not Applicable.


From 60 to 90 days. Renewals are made by competitive applications and Reviews.

Assistance Considerations

Formula and Matching Requirements

Statutory formulas are not applicable to this program. Matching requirements are not applicable to this program. MOE requirements are not applicable to this program.

Length and Time Phasing of Assistance

From one to five years. Throughout the project period, CDC's commitment to continuation of awards will be conditioned on the availability of funds, evidence of satisfactory progress by the recipient (as documented in required reports), and the determination that continued funding is in the best interest of the Federal Government. Method of awarding/releasing assistance: lump sum.

Post Assistance Requirements


As specified in the Funding Opportunity Announcement.

No cash reports are required.

As specified in the Funding Opportunity Announcement.

Recipients of PEPFAR funds are required to report annually on program expenditures.

Specifically, annual completion of PEPFAR Program Expenditures (Form DS-4213, approved by OMB 1405-0208, or the relevant OMB-approved format) will be required in conjunction with the PEPFAR Annual Progress Report at the completion of the USG fiscal year.

As specified in the Funding Opportunity Announcement.


In accordance with the provisions of 2 CFR 200, Subpart F - Audit Requirements, non-Federal entities that expend financial assistance of $750,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Non-Federal entities that expend less than $750,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in 2 CFR 200.503. Foreign recipients are subject to audit requirements specified in 45 CFR 74.26(d). A non-Federal audit is required, if during the recipients fiscal year, the recipient expended a total of $300,000.00 or more under one or more HHS awards (as a direct recipient and/or as a subrecipient) . The recipient either may have (1) A financial related audit (as defined in the Government Auditing Standards, GPO stock #020-000-00-265-4) of a particular award in accordance with Government Auditing Standards, in those case where the recipient receives awards under only one HHS program; or, if awards are received under multiple HHS programs, a financial related audit of all HHS awards in accordance with Government Auditing Standards; or (2) An audit that meets the requirements contained in OMB Circular A-133. Please forward a copy of the completed audit to the following address: Procurement and Grants Office, Centers for Disease Control and Prevention, Attn: Grants Management Officer, 2920 Brandywine Road, MS-K75, Atlanta, GA 30341. If your audit was completed in accordance with number two (2) above, in addition to the address listed above, you are required to send a copy of the audit report to: Department of Health & Human Services, National External Audit Review Center Lucas Place, Room 514, 323 West 8th Street, Kansas City, MO 64105.


The Recipient Agreement Books and Records. The recipient must maintain accounting books, records, documents and other evidence relating to the Agreement, adequate to show, without limitation, all costs incurred by the recipient, the receipt and use of goods and services acquired by the recipient, agreed-upon cost sharing requirements, the nature and extent of solicitations of prospective suppliers of goods and services acquired by the recipient, the basis of award of recipient contracts and orders, and the overall progress of the Agreement toward completion ('Agreement books and records'). The recipient must maintain Agreement books and records in accordance with generally accepted accounting principles prevailing in the United States, or at the recipient?s option, with approval by HHS/CDC, other accounting principles, such as those (1) prescribed by the International Accounting Standards Committee (an affiliate of the International Federation of Accountants), or (2) prevailing in the country of the recipient. Agreement books and records must be maintained for at least three years after the date of last disbursement by HHS/CDC or for such longer period, if any, required to resolve any litigation, claims or audit findings.

Financial Information

Account Identification



(Cooperative Agreements) FY 16 $2,354,719,081; FY 17 est $2,354,719,081; and FY 18 est $2,354,719,081

Range and Average of Financial Assistance

$25,000 to $48,000,000. Average $2,700,000.

Regulations, Guidelines, and Literature

45 CFR Part 74 and Part 92 For more information on the Code of Federal Regulations, see the National Archives and Records Administration at the following Internet address:

Information Contacts

Regional or Local Office

See Regional Agency Offices. Jamie Legier, Branch Chief, International Branch, (770)488-2613, 2920 Brandywine Road, Atlanta, GA 30341.

Headquarters Office

Caroline Gardner 1600 Clifton Road, NE, Mailstop E-29, Atlanta, Georgia 30333 Email: Phone: 404-639-4276

Criteria for Selecting Proposals

All applications will be initially reviewed for completeness by CDC Office of Grants Services (OGS) staff. Complete applications will be jointly reviewed for responsiveness by HHS/CDC Division of Global HIV and Tuberculosis and OGS Non-responsive applications will not advance to Phase II review. Applicants will be notified the application did not meet eligibility and/or published submission requirements. A review panel will evaluate complete, eligible applications in accordance with the criteria published in the Funding Opportunity Announcement. Applications will be funded in order by score and rank determined by the review panel unless funding preferences or other considerations stated in this FOA apply. Final selection and approval of activities will be prioritized in collaboration with CDC.

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