Research Infrastructure Programs

The Office of Research Infrastructure Programs (ORIP) is a program office in the Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) dedicated to supporting research infrastructure and related research programs.

ORIP consists of the Division of Comparative Medicine (DCM);

credit: Care2
and Division of Construction and Instruments (DCI).

Agency - Department of Health and Human Services

The Department of Health and Human Services is the Federal government's principal agency for protecting the health of all Americans and providing essential human services, especially to those who are least able to help themselves.

Relevant Nonprofit Program Categories

Selected Recipients for this Program

RecipientAmount Start DateEnd Date
Regents Of The University Of California, San Francisco, The $ 8,075,410   2012-04-042027-05-31
University Of Nebraska $ 114,064   2022-04-012027-03-31
University Of Georgia Research Foundation, Inc. $ 611,839   2006-04-012027-03-31
Regents Of The University Of Minnesota $ 4,812,470   2012-09-012027-02-28
Johns Hopkins University, The $ 117,127   2022-01-012026-12-31
Cornell University $ 139,299   2021-12-012026-11-30
Ohio State University, The $ 119,713   2021-07-052026-06-30
Colorado State University $ 37,913   2021-07-012026-06-30
Cornell University $ 42,516   2021-06-012026-06-30
University Of Missouri System $ 2,087,985   1977-07-012026-06-30

Program Accomplishments

Not Applicable.

Uses and Use Restrictions

The Division of Comparative Medicine (DCM) helps meet the needs of biomedical researchers for high-quality, disease-free animals and specialized animal research facilities.

Additionally, DCM seeks to increase small business participation in federally supported research and development as well as the private-sector commercialization of technology developed with federal support and the biomedical workforce of scientist with a background in veterinary medicine.

It does this through the federal government's Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs.

Division of Construction and Instruments: This Division supports programs to expand the Nation?s capacity for the conduct of biomedical research by offering grants for the acquisition of state-of the-art biomedical research instrumentation and integrated instrument systems, and grants to renovate, improve, or modernize existing research facilities.

Eligibility Requirements

Applicant Eligibility

Comparative Medicine: Institutions of higher education, hospitals, and other institutions and organizations, both nonprofit and for-profit, seeking to establish, continue, or enlarge programs consistent with the objectives of the program.

Applicants for NRSA must be citizens of the United States or be admitted to the United States for permanent residency.

Applicants must be nominated and sponsored by a public or private nonprofit institution with staff and facilities suitable for the proposed research training.

Nonprofit domestic organizations may apply for the institutional NRSA.

Research Career Development: Applications may be submitted on behalf of candidates by domestic, nonfederal organizations, public or private institutions of higher education.

Beneficiary Eligibility

Biomedical investigators at any nonprofit or for-profit organization, company, or institution engaged in biomedical research.


No Credentials or documentation are required. This program is excluded from coverage under 2 CFR 200, Subpart E - Cost Principles.

Aplication and Award Process

Preapplication Coordination

Preapplication coordination is required.

Environmental impact information is not required for this program.

This program is excluded from coverage under E.O.


Application Procedures

This program is excluded from coverage under 2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards. Application forms may be obtained from the Division of Extramural Outreach and Information, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910. Telephone (301) 435-0714, e-mail: . Completed applications should be submitted to the Center for Scientific Review, 6701 Rockledge Drive, MSC 7710, Bethesda, MD 20892-7710. The standard application forms PHS 398, (Rev. November 1998), as furnished by PHS and required by 45 CFR, Part 92 must be used for all programs. For filing NRSA individual fellowship award applications, Form 416-1 (Rev. October 1991) is needed.

Award Procedures

The initial review of applications from eligible investigators and institutions is reviewed by committees comprised of authorities in various fields of biomedical research and science education, as appropriate. Each application is given a peer evaluation for merit, and recommendations are forwarded to the Council of Councils for final review and recommendation.


Contact the headquarters or regional office, as appropriate, for application deadlines.


Small Business Research and Development Enhancement Act of 1992, Public Law 102-564; Public Health Service Act, Title IV, Section 487, Public Law 99-158; Public Health Service Act, Title III, Section 301, Public Law 78-410, 341 U.S.C 287-288.

Range of Approval/Disapproval Time

> 180 Days.


From 60 to 90 days. A principal investigator (P.I.) may question the substantive or procedural aspects of the review of their application by communicating with the NIH staff. A description of the NIH Peer Review Appeal procedures is available on the NIH home page .


> 180 Days. Renewal applications are reviewed in the same manner as new applications. Modernization and Instrumentation: None.

Assistance Considerations

Formula and Matching Requirements

This program has no statutory formula. This program has no matching requirements. This program does not have MOE requirements.

Length and Time Phasing of Assistance

All programs: 1 to 5 years. An Electronic Transfer System is used for transferring funds. Research Grants, Cooperative Agreements, Center Grants, and NRSA Institutional grants may be awarded for up to 5 years, generally in 12-month budget periods and may be extended through a competitive renewal. SBIR: Normally, Phase I awards are for 6 months; normally, Phase II awards are for 2 years. STTR: Normally, Phase I awards are for 1 year; normally, Phase II awards are for 2 years. The Council of Councils may recommend funding for periods ranging from 1 to 5 years. Funding commitments are made annually. Award length may vary depending on the recommendation of the scientific review group, the national advisory council, successful annual performance, and availability of funds. A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization. See the following for information on how assistance is awarded/released: An Electronic Transfer System is used for transferring funds.

Post Assistance Requirements


No program reports are required.

No cash reports are required.

Annual progress and financial status reports are required for all grants.

Final performance and financial reports are required 90 days following the end of the project period.

Annual progress and financial status reports are required for all grants.

Final performance and financial reports are required 90 days following the end of the project period.

No performance monitoring is required.


In accordance with the provisions of 2 CFR 200, Subpart F - Audit Requirements, non-Federal entities that expend financial assistance of $750,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Non-Federal entities that expend less than $750,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in 2 CFR 200.503. In accordance with the provisions of 45 CFR 75, nonfederal entities that expend financial assistance of $500,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Nonfederal entities that expend less than $500,000 a year in Federal awards are exempt from Federal audit requirements for that year. The regulation provides for profit organizations with the option for the type of audit that will satisfy the audit requirement that a financial related audit of the HHS awards in accordance with Government Auditing Standards In accordance with NIH grants policy, Foreign grantees are subject to the same audit requirements as for-profit (commercial) organizations.


Grantees generally must retain financial and programmatic records, supporting documents, statistical records, and all other records that are required by the terms of a grant, or may reasonably be considered pertinent to a grant, for a period of 3 years from the date the annual FSR is submitted. For awards under SNAP (other than those to foreign organizations and Federal institutions), the 3-year retention period will be calculated from the date the FSR for the entire competitive segment is submitted. Those grantees must retain the records pertinent to the entire competitive segment for 3 years from the date the FSR is submitted to NIH. Foreign organizations and Federal institutions must retain records for 3 years from the date of submission of the annual FSR to NIH. See 45 CFR 74.53 and 92.42 for exceptions and qualifications to the 3-year retention requirement (e.g., if any litigation, claim, financial management review, or audit is started before the expiration of the 3-year period, the records must be retained until all litigation, claims, or audit findings involving the records have been resolved and final action taken). Those sections also specify the retention period for other types of grant-related records, including F&A cost proposals and property records. See 45 CFR 74.48 and 92.36 for record retention and access requirements for contracts under grants. In accordance with 45 Code of Federal Regulations, Part 74.53(e), the HHS Inspector General, the U.S. Comptroller General, or any of their duly authorized representatives have the right of timely and unrestricted access to any books, documents, papers, or other records of recipients that are pertinent to awards in order to make audits, examinations, excerpts, transcripts, and copies of such documents. This right also includes timely and reasonable access to a recipient?s personnel for the purpose of interview and discussion related to such documents. The rights of access are not limited to the required retention period, but shall last as long as records are retained.

Financial Information

Account Identification



(Project Grants) FY 16 $265,638,377; FY 17 est $265,051,400; and FY 18 est $192,525,299 - (Project Grants) FY 15 $264,543,192; FY 16 est $264,187,662; and FY 17 est $264,187,662- Amounts shown are actual/estimated amounts available for research grants including SBIR/STTR, centers, research career awards, and research project grants. Amounts for research training grants, R&D contracts, and research management support are not included. (Project Grants (Capacity Building and Complaint Processing, Training)) FY 16 $7,659,219; FY 17 est $7,812,403; and FY 18 est $6,640,543 - (Project Grants (Training)) FY 15 $6,514,392; FY 16 est $7,787,235; and FY 17 est $7,787,235 - Amounts shown are for individual and institutional research training awards.

Range and Average of Financial Assistance

Awards vary in range depending on the particular activity codes. Research Centers grants have much larger ranges - from hundreds of thousands to several million dollars. All costs are shown on a single year basis. Awards may be for up to five years.

Regulations, Guidelines, and Literature

Reference: 44 FR 12368, March 6, 1979; Rev. No. 1, 47 FR 33658, August 3, 1982; Rev. No. 2, 51 FR 20908, June 9, 1986.Reference: 41 FR 32016, July 30, 1976. Reference: 34 CFR 255. 45 CFR 92. Reference: 42 FR 45828. 42 CFR 52h. Grants will be available under the authority of and administered in accordance with the PHS Grants Policy Statement and Federal Regulations at 42 CFR 52 and 42 USC 241. Department Staff Manual 'Grants Administration'; Indirect Cost Register, DHHS; PHS Grants Policy Statement, DHHS Publications No. (OASH) 94-50,000, (Rev.) April 1, 1994; 'NIH Grants Policy Guide,' Office for Protection from Research Risks, NIH; 'A Guide to Grant and Award Programs of the NIH'; and miscellaneous program literature from Headquarters Office.

Information Contacts

Regional or Local Office


Headquarters Office

Patricia Newman 6701 Democracy Boulevard Room 956-MSC4874, Bethesda, Maryland 20892-4874 Email: Phone: 3014350864

Criteria for Selecting Proposals

The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives.

Social Entrepreneurship

Rwanda as Social Entrepreneur Fund Beneficiary

The Republic of Rwanda has been picked as one of the six African countries as beneficiaries for a new fellowship fund program designed at supporting social entrepreneurs in tackling issues on food security.

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