21st Century Cures Act - Beau Biden Cancer Moonshot

To provide support for initiatives funded under the 21st Century Cures Act to support cancer research, such as the development of cancer vaccines, the development of more sensitive diagnostic tests for cancer, immunotherapy and the development of combination therapies, and research that has the potential
to transform the scientific field, that has inherently higher risk, and that seeks to address major challenges related to cancer.

Agency - Department of Health and Human Services

The Department of Health and Human Services is the Federal government's principal agency for protecting the health of all Americans and providing essential human services, especially to those who are least able to help themselves.

Office - None.

Not applicable.

Selected Recipients for this Program

RecipientAmount Start DateEnd Date
University Of New Mexico $ 36,654,277   2005-09-262026-08-31
Sloan-kettering Institute For Cancer Research $ 3,057,336   2016-08-222026-07-31
University Of Texas Southwestern Medical Center, The $ 27,205,773   2010-08-032026-07-31
University Of California, Davis $ 49,956,059   2002-07-012026-06-30
University Of Rochester $ 1,063,330   2020-06-012026-05-31
Wayne State University $ 40,595,708   1997-08-082025-11-30
University Of North Carolina At Chapel Hill $ 113,237,485   1997-06-012025-11-30
President And Fellows Of Harvard College $ 1,532,606   2021-09-242025-08-31
Icahn School Of Medicine At Mount Sinai $ 1,542,450   2021-09-232025-08-31
University Of California, Santa Cruz $ 1,454,162   2021-09-212025-08-31

Program Accomplishments

Not Applicable.

Uses and Use Restrictions

Grants and cooperative agreements may be made to eligible institutions for the support of cancer research projects.

The grants and cooperative agreements may be used for personnel, consultant costs, equipment, supplies, travel, patient costs, animals, alterations and renovations, miscellaneous items, and Facilities and Administrative Costs (formerly known as indirect costs).

Eligibility Requirements

Applicant Eligibility

The awardee will be a university, college, hospital, public agency, nonprofit research institution or for-profit organization that applies and receives a grant for support of research by a named principal investigator.

To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council.

Beneficiary Eligibility

Any nonprofit or for-profit organization, company, or institution engaged in biomedical research.


Applications must be submitted in compliance with instructions provided with each initiative. 2 CFR 200, Subpart E - Cost Principles applies to this program.

Aplication and Award Process

Preapplication Coordination

Preapplication coordination is not applicable.

Environmental impact information is not required for this program.

This program is excluded from coverage under E.O.


Application Procedures

2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program.

Award Procedures

Grants and cooperative agreements are funded based on scientific merit, program relevance, and program balance and are made annually. The initial grant award provides funds for the first budget period (usually 12 months) and letter Notice of Award indicates support recommended for the remainder of the project period, allocation of Federal funds by budget categories and special conditions, if any.


Not Applicable.


Act: Public Health Service Act, Sections 301, 410 and 412, Public Law 78-410, as amended, Public Law 99-500, Public Law 100-607, 42 U.S.C. 241, 42 U.S.C. 285 - 285a-1; Small Business Research and Development Enhancement Act of 1992, Public Law 102-564.

Range of Approval/Disapproval Time

Regular Grants: Approximately 10 months.


From 15 to 30 days. A principal investigator may question the substantive or procedural aspects of the review of his/her application by communicating with the staff of the Institute. A description of the NIH Peer Review Appeal procedures is available on the NIH home page www.nih.gov/grants/guide/notice-files/not97-232.html .


From 30 to 60 days. Applications submitted for renewal are reviewed and selected for funding on a competitive basis.

Assistance Considerations

Formula and Matching Requirements

Statutory formulas are not applicable to this program. Matching requirements are not applicable to this program. MOE requirements are not applicable to this program.

Length and Time Phasing of Assistance

Grants and Cooperative Agreements: Average 3 to 5 years, and a maximum of 5 years. Renewals may be awarded for additional periods of up to 5 years based on competitive peer review. Method of awarding/releasing assistance: by letter of credit.

Post Assistance Requirements


No program reports are required.

No cash reports are required.

Annual progress reports and selected financial reports are required for continuing projects.

Final progress reports, invention statements, and expenditure reports are required at the end of the projects.

Special reports may be requested by DHHS.

Final progress reports, invention statements, and expenditure reports are required at the end of the projects.

Special reports may be requested by DHHS.

No performance monitoring is required.


In accordance with the provisions of 2 CFR 200, Subpart F - Audit Requirements, non-Federal entities that expend financial assistance of $750,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Non-Federal entities that expend less than $750,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in 2 CFR 200.503. Expenditures and other financial records, and also administrative records, must be retained for 3 years from the day on which the grantee submits the last expenditure report for the grant period.


Expenditures and other financial records, and also administrative records, must be retained for 3 years from the day on which the grantee submits the last expenditure report for the grant period.

Financial Information

Account Identification



(Salaries) FY 16 Not Available; FY 17 Not Separately Identifiable; and FY 18 Not Separately Identifiable

Range and Average of Financial Assistance

No Data Available.

Regulations, Guidelines, and Literature

45 CFR 75, NIH Grants Policy Statement, SF 424

Information Contacts

Regional or Local Office

None. Not applicable.

Headquarters Office

Catherine M. Battistone 9609 Medical Center Drive, Suite 7W532, Rockville, Maryland 20850 Email: battistc@mail.nih.gov Phone: 240-276-6443 Fax: 240-276-7682

Criteria for Selecting Proposals

Funding decisions are based on scientific merit (42 CFR 52h) and program relevance. Scientific merit review encompasses: the peer review criteria detailed in the specific funding announcement, as well as the significance, approach, and innovation of the proposed research; the competency of the principal investigator; the adequacy of the resources and environment; the proposed budget and requested period of support; and, where applicable, the adequacy of the measures for protecting against adverse effects upon humans, animals, or the environment.

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