National Center for Research Resources

The National Center for Research Resources (NCRR) provides laboratory scientists and clinical researchers with the environments and tools they need to understand, detect, treat, and prevent a wide range of diseases.

This support enables discoveries that begin at a molecular and cellular level,
move to animal-based studies, and then are translated to patient-oriented clinical research, resulting in cures and treatments for both common and rare diseases.

NCRR connects researchers with one another and with patients and communities across the nation to harness the power of shared resources and research.

Agency - Department of Health and Human Services

The Department of Health and Human Services is the Federal government's principal agency for protecting the health of all Americans and providing essential human services, especially to those who are least able to help themselves.

Website Address

http://www.nih.gov




Selected Recipients for this Program


RecipientAmount Start DateEnd Date
Ada Technologies, Inc. $ 1,148,318   2007-02-013012-04-30
Miami University $ 937,461   2011-07-012018-07-31
University Of Washington $ 379,800   2011-09-142016-08-31
Leland Stanford Junior University, The $ 129,330   2011-09-012016-08-31
Hugo W. Moser Research Institute At Kennedy Krieger, Inc. $ 7,773,408   2000-07-012016-08-31
University Of Texas Health Science Center Of San Antonio $ 536,243   2011-09-052016-08-31
Cornell University, Inc $ 5,708,841   2001-09-152016-08-31
Mississippi State University $ 263,605   2011-09-012016-08-30
Medical University Of South Carolina $ 2,152,854   2011-09-012016-07-31
University Of Louisville $ 1,117,500   2011-08-012016-07-31



Program Accomplishments

Not Applicable.

Uses and Use Restrictions

The Division of Biomedical Technology supports research, development and access to sophisticated technologies at resource centers nationwide which assist academic, nonprofit organizations in the development, use, and dissemination of innovative technologies useful for the advancement of biomedical science.

Awards are provided under a variety of funding mechanisms composed of Biomedical Technology Resource(BTR) grants, Research Project Grants, Shared Instrumentation Grants (SIG), High End Instrumentation (HEI) Program and other mechanisms, such as Exploratory Grants to develop new technologies for biomedical research, Small Business Innovation Research (SBIR) grants, and Small Business Technology Transfer (STTR) grants.

The Division for Clinical Research Resources makes it possible to apply knowledge gained through basic research to the development of lifesaving drugs, devices, and therapies that protect the health of our nation's citizens by providing research infrastructure for clinical investigators.

These specialized institutional resources are equipped to be flexible and responsive to changing scientific and economic environments and to unforeseen research challenges.

The Division for Clinical Research Resources helps translate scientific knowledge into effective patient care through General Clinical Research Centers (GCRC), Research Career Development (K23, K24), Clinical Research Curriculum Award (CRCA, K30), Cinical Research-related activities, Small Business Innovation Research (SBIR) grants and Small Business Technology Transfer (STTR) grants; and improves pre-college science education and the public's understanding of science through the Science Education Partnership Award (SEPA) Program.

Additionally, a new consortium, funded through Clinical and Translational Science Awards (CTSAs), will transform how clinical and translational research is conducted, ultimately enabling researchers to provide new treatments more efficiently and quickly to patients.

The Division of Comparative Medicine supports research and resource projects, as well as centers that enable biomedical scientists to use high quality, disease-free animals effectively in research on human health problems.

Support is also available for the development of a wide range of other research models, particularly marine invertebrates and lower vertebrates, and access to an array of important biological materials.

These objectives are accomplished through activities of National Primate Research Centers (NPRC), Laboratory Animal Science (LAS), and Biological Models and Materials Research (BMMR).

The Division of Research Infrastructure addresses the under representation of minority investigators; enhances the research environment at minority colleges and universities in the health sciences; broadens the geographic distribution of research grant funding to states with historically low NIH success rates; and improves biomedical research facilities through matching grants for construction and renovation.

These objectives are accomplished through activities of the Research Centers in Minority Institutions (RCMI) program, the RCMI Clinical Research Infrastructure Initiative (RCRII), and the Institutional Developmental Award (IDeA).

The Office of Construction supports the Research Facilities Improvement Program (RFIP) and the Animal Facilities Improvement Program.

Eligibility Requirements

Applicant Eligibility

BTR Grants: Nonprofit health professional schools; other academic institutions; hospitals; State and local health agencies; and research organizations with programs in biomedical technology research located in the United States and its territories.

SIG and HEI awards will be made to institutions only, not to individuals.

GCRC and CTSA grants: schools, research hospitals, and other institutions capable of carrying out well-designed studies in any preclinical or clinical science involving human beings as research subjects in conjunction with investigators funded through the National Institutes of Health (NIH) and other Federal agencies.

Research Career Development: Applications may be submitted on behalf of candidates by domestic, nonfederal organizations, public or private institutions of higher education.

Clinical Research Scholar Program Award: Applications will be accepted from domestic, nonprofit organizations, public and private institutions of higher education that have strong, well-established clinical research and training program.

SEPA: Public and private for-profit and nonprofit institutions and museums.

DCM: Institutions of higher education, hospitals, and other institutions and organizations, both nonprofit and for-profit, seeking to establish, continue, or enlarge programs consistent with the objectives of the program.

Applicants for NRSA must be citizens of the United States or be admitted to the United States for permanent residency.

Applicants must be nominated and sponsored by a public or private nonprofit institution with staff and facilities suitable for the proposed research training.

Nonprofit domestic organizations may apply for the institutional NRSA.

RCMI: Institutions with more than 50 percent minority enrollment that award an M.D., D.D.S., D.V.M., or other doctoral degree in the health professions and/or a Ph.D.

in the health-related sciences.

This program is open only to institutions within the United States and its territories.

RCRII: RCMI eligible institutions affiliated with medical schools.

IDeA: Domestic public and private for profit and nonprofit institutions in States in which the success rate for applications to the NIH has been historically low.

RFIP and Animal Facilities Improvement: Except where otherwise prohibited by law, any nonprofit organization competent to carry out biomedical research.

Beneficiary Eligibility

Biomedical investigators at any nonprofit or for-profit organization, company, or institution engaged in biomedical research.

Credentials/Documentation

SIG, HEI: A major user group of three or more investigators should be identified. Each major user must have NIH peer-reviewed research support at the time of the award. The application must show a clear need for the instrumentation by projects supported by multiple NIH research awards and demonstrate that these projects will require at least 75 percent of the total usage of the instrument. Applications for NRSA must be citizens of the United States or be admitted to the United States for permanent residency. Applicants must be nominated and sponsored by a public or private nonprofit institution with staff and facilities suitable for the proposed research training. Nonprofit domestic organizations may apply for the institution NRSA. RCMI, RCRII, and CCRE: Applicants must certify eligibility (see Applicant Eligibility requirements). IDeA, and Animal Facilities Improvement: None. RFIP: Application should include a complete research program description (with staff curricula vitae), space requirements for projected program, an environmental summary of the impact of the proposed facility as detailed in Public Law 90-190, The National Environmental Policy Act, and listing of all relevant licenses, permits or other approvals required by State and local authorities. Costs will be determined in accordance with OMB Circular Nos. A-122, 'Cost Principles for Nonprofit Organizations,' and in the case of SIG & HEI No. A-87 for State and local governments or A-21 for Educational Institutions, and HHS Regulations 45 CFR, Part 74, Subpart Q. 2 CFR 200, Subpart E - Cost Principles applies to this program.

Aplication and Award Process

Preapplication Coordination

Preapplication coordination is required.

Environmental impact information is not required for this program.

This program is eligible for coverage under E.O.

12372, 'Intergovernmental Review of Federal Programs.' An applicant should consult the office or official designated as the single point of contact in his or her State for more information on the process the State requires to be followed in applying for assistance, if the State has selected the program for review.

Application Procedures

This program is excluded from coverage under 2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards. Application forms may be obtained from the Division of Extramural Outreach and Information, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910. Telephone (301) 435-0714, e-mail: ASKNIH@odrockml.od.nih.gov . Completed applications should be submitted to the Center for Scientific Review, 6701 Rockledge Drive, MSC 7710, Bethesda, MD 20892-7710. The standard application forms PHS 398, (Rev. November 1998), as furnished by PHS and required by 45 CFR, Part 92, and OMB Circular No. A-110 must be used for all programs. For filing NRSA individual fellowship award applications, Form 416-1 (Rev. October 1991) is needed. CTSA: Special instructions for preparing applications should be requested from the Division for Clinical Research Resources, One Democracy Plaza, 6701 Democracy Blvd., National Center for Research Resources, National Institutes of Health, Bethesda, MD 20892-4874. RFIP: Construction applications are to be submitted on a Standard Form 424, Application for Federal Assistance.

Award Procedures

The initial review of applications from eligible investigators and institutions is reviewed by committees comprised of authorities in various fields of biomedical research and science education, as appropriate. Each application is given a peer evaluation for merit, and recommendations are forwarded to the National Advisory Research Resources Council for final review and recommendation.

Deadlines

Contact the headquarters or regional office, as appropriate, for application deadlines.

Authorization

Public Health Service Act, Title III, Section 301, Public Law 78-410, U.S.C 341, 287-288; Small Business Research and Development Enhancement Act of 1992, Public Law 102-564; Public Health Service Act, Title IV, Section 479-480 487, Public Law 99-158.

Range of Approval/Disapproval Time

> 180 Days.

Appeals

A principal investigator (P.I.) may question the substantive or procedural aspects of the review of their application by communicating with the NCRR staff. A description of the NIH Peer Review Appeal procedures is available on the NIH home page www.nih.gov/grants/guide/1997/97.11.21/n2.html .

Renewals

K23, K24, SIG, HEI, Animal Facilities Improvement, and RFIP: None. All others may be renewed upon successful reapplication.

Assistance Considerations

Formula and Matching Requirements

This program has no statutory formula. This program has no matching requirements. This program does not have MOE requirements.

Length and Time Phasing of Assistance

All programs except for RFIP: 1 to 5 years. An Electronic Transfer System is used for transferring funds. RFIP: Construction must be completed within the time specified in grant award. The initial budget period is usually 2 years in length, although extensions may be requested. All funds must be obligated within 5 years from the date of award. See the following for information on how assistance is awarded/released: All programs except for RFIP: 1 to 5 years. An Electronic Transfer System is used for transferring funds. RFIP: Construction must be completed within the time specified in grant award. The initial budget period is usually 2 years in length, although extensions may be requested. All funds must be obligated within 5 years from the date of award.

Post Assistance Requirements

Reports

No program reports are required.

No cash reports are required.

Annual progress and financial status reports are required for all grants.

Final performance and financial reports are required 90 days following the end of the project period.

Reports are required after termination of NRSA to ascertain compliance with the service and payback provisions.

RFIP: The grantee is responsible for performance of the contractor.

The contractor must be covered by performance and payment bonds.

Annual progress and financial status reports are required for all grants.

Final performance and financial reports are required 90 days following the end of the project period.

Reports are required after termination of NRSA to ascertain compliance with the service and payback provisions.

RFIP: The grantee is responsible for performance of the contractor.

The contractor must be covered by performance and payment bonds.

No performance monitoring is required.

Audits

In accordance with the provisions of 2 CFR 200, Subpart F - Audit Requirements, non-Federal entities that expend financial assistance of $750,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Non-Federal entities that expend less than $750,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in 2 CFR 200.503.

Records

Grantees generally must retain financial and programmatic records, supporting documents, statistical records, and all other records that are required by the terms of a grant, or may reasonably be considered pertinent to a grant, for a period of 3 years from the date the annual FSR is submitted. For awards under SNAP (other than those to foreign organizations and Federal institutions), the 3-year retention period will be calculated from the date the FSR for the entire competitive segment is submitted. Those grantees must retain the records pertinent to the entire competitive segment for 3 years from the date the FSR is submitted to NIH. Foreign organizations and Federal institutions must retain records for 3 years from the date of submission of the annual FSR to NIH. See 45 CFR 74.53 and 92.42 for exceptions and qualifications to the 3-year retention requirement (e.g., if any litigation, claim, financial management review, or audit is started before the expiration of the 3-year period, the records must be retained until all litigation, claims, or audit findings involving the records have been resolved and final action taken). Those sections also specify the retention period for other types of grant-related records, including F&A cost proposals and property records. See 45 CFR 74.48 and 92.36 for record retention and access requirements for contracts under grants. In accordance with 45 Code of Federal Regulations, Part 74.53(e), the HHS Inspector General, the U.S. Comptroller General, or any of their duly authorized representatives have the right of timely and unrestricted access to any books, documents, papers, or other records of recipients that are pertinent to awards in order to make audits, examinations, excerpts, transcripts, and copies of such documents. This right also includes timely and reasonable access to a recipient?s personnel for the purpose of interview and discussion related to such documents. The rights of access are not limited to the required retention period, but shall last as long as records are retained.

Financial Information

Account Identification

75-0848-1-1-552.

Obigations

(Project Grants) FY 16 $0; FY 17 est $0; and FY 18 est $0 - Research Centers in Minority Institutions Centers. (Project Grants) FY 16 $0; FY 17 est $0; and FY 18 est $0 - Biomedical Technology Research Centers. (Project Grants) FY 16 $0; FY 17 est $0; and FY 18 est $0 - Comparative Medicine Centers. (Project Grants) FY 16 $0; FY 17 est $0; and FY 18 est $0 - Special Comprehensive Centers. No funding for this program after FY2011. (Project Grants) FY 16 $0; FY 17 est $0; and FY 18 est $0 - Other Research. (Project Grants) FY 16 $0; FY 17 est $0; and FY 18 est $0 - General Clinical Research Centers/Clinical and Translational Science Awards Centers. (Project Grants) FY 16 $0; FY 17 est $0; and FY 18 est $0 - Research Project Grants. (Project Grants (Capacity Building and Complaint Processing, Training)) FY 16 $0; FY 17 est $0; and FY 18 est $0 - Research Training. (Project Grants (Contracts)) FY 16 $0; FY 17 est $0; and FY 18 est $0 - Research & Development Contracts.

Range and Average of Financial Assistance

No new funding for this program since FY2011. Grants still remain active.

Regulations, Guidelines, and Literature

BT: OMB Circular No. A-21, 'Cost Principles for Educational Institutions.' Reference: 44 FR 12368, March 6, 1979; Rev. No. 1, 47 FR 33658, August 3, 1982; Rev. No. 2, 51 FR 20908, June 9, 1986. OMB Circular No. A-110, 'Grants and Agreements with Institutions of Higher Education, Hospitals, and Other Nonprofit Organizations.' Reference: 41 FR 32016, July 30, 1976. OMB Circular No. A-122, 'Cost Principles for Nonprofit Organizations.' OMB Circular No. A-128, 'Audits of State and Local Governments'; Reference: Public Law 98-502, the Single Audit Act of 1984. OMB Circular No. A-87, 'Cost Principles Applicable to Grants and Contracts with State and Local Governments'; Reference: 34 CFR 255. 45 CFR 92. Reference: 42 FR 45828. OMB Circular No. A-122, 'Cost Principles for Nonprofit Organizations.' Reference: 45 FR 46022, July 8, 1980. 45 CFR 74; 42 CFR 52h. Grants will be available under the authority of and administered in accordance with the PHS Grants Policy Statement and Federal Regulations at 42 CFR 52 and 42 USC 241. Department Staff Manual 'Grants Administration'; Indirect Cost Register, DHHS; PHS Grants Policy Statement, DHHS Publications No. (OASH) 94-50,000, (Rev.) April 1, 1994; 'NIH Grants Policy Guide,' Office for Protection from Research Risks, NIH; 'A Guide to Grant and Award Programs of the NIH'; and miscellaneous program literature from Headquarters Office.

Information Contacts

Regional or Local Office

None.

Headquarters Office

Patricia Newman, 6701 Democracy Boulevard ,MSC4874 , Bethesda, Maryland 20892-4874 Email: pnewman@mail.nih.gov Phone: (301) 435-0864.

Criteria for Selecting Proposals

The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. RFIP: Factors considered in making awards include the merit of the proposal, the needs of the institution, with special consideration for institutions designated as centers of excellence, the commitment of the institution, the availability of funds, and the overall program priorities.



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