Cancer Centers Support Grants

To provide an organizational focus and stimulus for the highest quality cancer research that effectively promotes interdisciplinary cancer research aimed toward the ultimate goal of reducing cancer incidence, mortality and morbidity.

The Cancer Center Support Grant (CCSG) provides the resources

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and infrastructure to facilitate the coordination of interdisciplinary programs across a broad spectrum of research from basic laboratory research to clinical investigation to population science.

The CCSG supports salaries for scientific leadership of the Center, shared resources for funded center investigators, certain administrative costs, planning and evaluation, and developmental funds for new recruitments and feasibility studies.

Agency - Department of Health and Human Services

The Department of Health and Human Services is the Federal government's principal agency for protecting the health of all Americans and providing essential human services, especially to those who are least able to help themselves.

Office - None.


Relevant Nonprofit Program Categories

Selected Recipients for this Program

RecipientAmount Start DateEnd Date
Oregon Health & Science University $ 34,840,064   1998-06-222027-06-30
Leland Stanford Junior University, The $ 47,826,101   2007-06-042027-05-31
University Of Miami $ 23,831,792   2007-06-012027-05-31
Emory University $ 40,324,650   2002-09-302027-05-31
Albert Einstein College Of Medicine $ 13,751,068   2017-05-012027-04-30
Johns Hopkins University, The $ 44,766,677   2012-05-022027-04-30
Case Western Reserve University $ 22,992,458   1997-04-012027-04-30
University Of California, Los Angeles $ 2,129,402   2022-04-082027-03-31
University Of Alabama At Birmingham $ 92,921,042   1997-03-282027-03-31
H. Lee Moffitt Cancer Center And Research Institute Hospital, Inc. $ 53,486,525   1998-02-182027-01-31

Program Accomplishments

Fiscal Year 2016: In fiscal Year 2016, 217 total Centers were funded including 69 Centers, 50 SPOREs, and 98 Specialized Centers. Fiscal Year 2017: Fiscal year 2017 will fund an estimated 219 total Centers that will include 69 Centers, 49 SPOREs and 101 Specialized Centers. Fiscal Year 2018: Fiscal Year 2018 will fund 202 total Centers that will include 69 Centers, 49 SPOREs, and 84 Specialized Centers.

Uses and Use Restrictions

In general, CCSGs do not support research projects directly but are used to enhance the ongoing cancer research and to strengthen the existing research base according to the 'Policies and Guidelines Relating to the Cancer Center Support Grant.'.

Eligibility Requirements

Applicant Eligibility

Any nonprofit institution within the United States with a peer-reviewed cancer research base of 4.0 million dollars in direct costs may apply for a Cancer Center Support Grant.

Beneficiary Eligibility

University, college, public agency or research institution in the U.S.


The application requests documentation concerning the qualifications of the principal investigators and associates, pertinent budget information and justification for the support of this proposed grant. Methods to be utilized are outlined in the application materials. Costs will be determined in accordance with HHS Regulations 45 CFR, Part 75. 2 CFR 200, Subpart E - Cost Principles applies to this program.

Aplication and Award Process

Preapplication Coordination

Preapplication coordination is not applicable.

Environmental impact information is not required for this program.

This program is excluded from coverage under E.O.


Application Procedures

2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. Method of Application: Form PHS-398 (Rev. June 2009) can be obtained from the website (click on PHS-398). In addition, supplemental instructions for applications are contained in the Cancer Center Support Grant Guidelines, Generally, the potential applicant should send a letter of intent to the National Cancer Institute, Office of Cancer Centers, submitting a CCSG application to the same address for review (see Guidelines for CCSGs). Completed applications should be submitted to the Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892.

Award Procedures

Grants are funded based on scientific merit, program relevance, and program balance and are made annually. Initial award provides funds for the first budget period (usually 12 months) and Notice of Grant Award (Form PHS 1533) indicates support recommended for the remainder of the project period, allocation of Federal funds by budget categories and special conditions, if any.


Contact the headquarters or regional office, as appropriate, for application deadlines.


Public Health Service Act, Section 305(a), 410, 411, and 414, Public Law 78-410, 42 U.S.C. 241, as amended; Public Law 100-607, 42 U.S.C. 285, 285a and 285a-3; Public Law 99-500.

Range of Approval/Disapproval Time

Core Grants: Approximately 10 months.


A principal investigator may question the substantive or procedural aspects of the review of his/her application by communicating with the staff of the Institute. A description of the NIH Peer Review Appeal procedures is available on and NIH Policy Manual Release date: February 7, 2012


Same procedure as new applications.

Assistance Considerations

Formula and Matching Requirements

This program has no statutory formula. Matching requirements are not applicable to this program. MOE requirements are not applicable to this program.

Length and Time Phasing of Assistance

Up to 5 years of support may be requested. Grants may be awarded up to 5 years based on competitive peer review. Method of awarding/releasing assistance: by letter of credit.

Post Assistance Requirements


No program reports are required.

No cash reports are required.

Progress reports are required each year.

An annual financial status report is requested 90 days after the end of the budget period.

Special reports may be requested by DHHS.

Terminal reports are required 90 days after the end of a project.

No expenditure reports are required.

No performance monitoring is required.


In accordance with the provisions of 2 CFR 200, Subpart F - Audit Requirements, non-Federal entities that expend financial assistance of $750,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Non-Federal entities that expend less than $750,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in 2 CFR 200.503. In addition, grants and cooperative agreements are subject to inspection and audits by DHHS and other Federal officials.


Expenditures and other financial records must be retained for 3 years from the day on which the grantee submits the last financial status report for the report period.

Financial Information

Account Identification

75-0849-0-1-550 - Cancer Center Support Grants.


(Project Grants) FY 16 $545,296,000; FY 17 est $544,194,000; and FY 18 est $504,000,000 - Cancer Centers Support Grants. FY2016 act. $545,296,000 FY2017 est. $544,194,000 FY2018 est. $504,000,000.

Range and Average of Financial Assistance

Range: $76,675 to $12,352,942 Average: $2,512,885.

Regulations, Guidelines, and Literature

42 CFR 52; 45 CFR 75; PHS Grants Policy Statement, DHHS Publication No. (OASH) 90- 50,000, (Rev.) October 1, 1990.

Information Contacts

Regional or Local Office

None. None.

Headquarters Office

Shamala K. Srinivas 9609 Medical Center Drive Seventh Floor, West Tower, 7W530, MSC 9750, Rockville, Maryland 20850 Email: Phone: 240-276-6442 Fax: 240-276-7682

Criteria for Selecting Proposals

The major elements in evaluating applications include the following: (1) An adequate base of established programs of high quality in laboratory and clinical cancer research; (2) research activity in a variety of disciplines, and evidence of high degree of interdisciplinary coordination, interaction and cooperation among center members; (3) appropriate and adequate organization and facilities for the conduct and evaluation of center activities; (4) a qualified director with adequate authority; and (5) an adequate commitment of the parent institution or institutions to the cancer center. The center should be recognized as a major element within the organizational structure.

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