Extramural Research Programs in the Neurosciences and Neurological Disorders

(1) To support extramural research funded by the National Institute of Neurological Disorders and Stroke (NINDS) including: basic research that explores the fundamental structure and function of the brain and the nervous system; research to understand the causes and origins of pathological conditions

credit:
of the nervous system with the goal of preventing these disorders; research on the natural course of neurological disorders; research on mechanisms associated with stroke and other cerebrovascular disorders, effects of trauma to the nervous system, neuroplasticity and regeneration, and tumors of neural tissues; improved methods of disease prevention; new methods of diagnosis and treatment; clinical trials; drug development; development of neural prostheses for stroke and paraplegia; epidemiological research; and research training in clinical neuroscience.

The Institute supports research on topics including but not limited to stroke; traumatic injury to the brain, spinal cord and peripheral nervous system; neurodegenerative disorders; brain tumors; development of artificial prosthetic devices to restore function to the damaged nervous system; convulsive disorders; infectious disorders of the brain and nervous system; immune disorders of the brain and nervous system, including multiple sclerosis; disorders related to sleep; and pain.

Programmatic areas also include neurodevelopment, repair and plasticity, channels synapses and circuits, neurogenetics, neurodegeneration, neural environment, and systems and cognitive neuroscience.

Extramural research is also supported by the Office of Training and Workforce Development, the Office of Programs to Enhance Neuroscience Workforce Development, the Office of International Activities, the Division of Extramural Activities, the Division of Translational Research, the Division of Clinical Research.

(2) To expand and improve the Small Business Innovation Research (SBIR) program; to increase private sector commercialization of innovations derived from Federal research and development; to increase small business participation in Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation.

(3) To utilize the Small Business Technology Transfer (STTR) program; to stimulate and foster scientific and technological innovation through cooperative research and development carried out between small business concerns and research institutions; to foster technology transfer between small business concerns and research institutions; to increase private sector commercialization of innovations derived from Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation.

The NINDS also participates in the Academic Research Enhancement Award (AREA) Program, which is intended to provide research support to institutions currently having little support from the National Institutes of Health (NIH) support.

Agency - Department of Health and Human Services

The Department of Health and Human Services is the Federal government's principal agency for protecting the health of all Americans and providing essential human services, especially to those who are least able to help themselves.

Office - None.

National Institute of Neurological Disorders and Stroke (NINDS), Division of Extramural Research (DER), National Institutes of Health, Department of Health and Human Services, Neuroscience Center, 6001 Executive Boulevard, Bethesda, MD 20892.

Director DER: Dr. Robert Finkelstein, Suite 3309, Telephone: (301) 496- 9248.

The address above (include suite #'s below) should be used for each Program Contact: Dr. Patrick Bellgowan, Repair and Plasticity, Suite 2205, Telephone: (301) 496-1447; Dr. Francesca Bosetti, Neural Environment, Suite 2115, Telephone: (301) 496-1431; Dr. Beth-Anne Sieber, Neurodegeneration, Suite 2223, Telephone: (301) 496-5680; Dr. Janet He, Systems & Cognitive Neuroscience, Suite 2227, telephone: (301) 496-9964; Dr. Vicky Whittemore, Channels, Synapses & Circuits, Suite 2133, Telephone: (301) 496-1917; Dr. Robert Riddle, Neurogenetics, Suite 2156, Telephone: (301) 496-5745; Dr. Claudia Moy, Office of International Activities, Suite 2214, Telephone: 301-496-9135; Dr. Elizabeth McNeil, Office of Clinical Research, Suite 2213, Telephone: (301) 496-9135; Dr. Alan Willard, Office of Translational Research, Suite 3279, Telephone: (301) 496-9746; Grants Management Branch: Ms. Tijuanna DeCoster, Grants Management Officer, Suite 3258, Telephone: (301) 496-9231; Contracts Management Branch: Mr. Kirk Davis, Contracts Management Officer, Suite 3280, Telephone: (301) 496-1813; Dr. Stephen Korn, Office of Training, Career Development, and Workforce Diversity Officer, Suite 2186, Telephone: (301) 496-4188.




Selected Recipients for this Program


RecipientAmount Start DateEnd Date
Baylor College Of Medicine $ 1,060,330   2017-12-152025-11-30
Scripps Research Institute, The $ 1,354,500   2017-12-152025-11-30
Children's Hospital Corporation, The $ 1,390,868   2017-12-152025-11-30
Leland Stanford Junior University, The $ 1,145,098   2017-12-152025-11-30
Sloan-kettering Institute For Cancer Research $ 601,125   2018-01-012025-11-30
Regents Of The University Of California, San Francisco, The $ 1,321,412   2017-12-152025-11-30
Regents Of The University Of California, San Francisco, The $ 1,982,533   2017-12-152025-11-30
Rockefeller University, The $ 1,892,597   2018-01-012025-11-30
Rockefeller University, The $ 3,402,508   2016-12-012024-11-30
Regents Of The University Of California, San Francisco, The $ 3,365,648   2016-12-012024-11-30



Program Accomplishments

Fiscal Year 2016: There were 842 competing research applications awards made. Fiscal Year 2017: There will be 699 competing research application awards made. Fiscal Year 2018: There will be 366 competing research application awards made.

Uses and Use Restrictions

Research grants may be used to provide salaries, equipment, supplies, travel and other expenses for research.

The grantee institution is obliged to expend grant funds prudently for the purposes stated in the application and award document.

National Research Service Awards (NRSAs) are made directly to individuals for research training in specified biomedical shortage areas, or to institutions, to enable them to make NRSAs to individuals selected by them.

Each individual who receives a NRSA may be obligated upon termination of the award to comply with service and payback provisions.

Career Development Awards such as the Independent Scientist Awards (K02) provide support for newly independent scientists with health-related degrees who can demonstrate the need for a period of intensive research focus as a means of enhancing their research careers and facilitating their ability to obtain major NIH research awards.

Mentored Clinical Research Scientist Development Awards (K08) provide support for clinically trained health professionals who need an additional period of sponsored research experience as a way to gain expertise in a research area new to the candidate or in an area that would demonstrably enhance the candidate's scientific career.

The K01 and K22 Mentored Research Scientist Development Awards are used to promote diversity in neuroscience research and support an intensive supervised research career development experience for underrepresented, disabled or disadvantaged career neuroscientists.

The Mentored Patient-Oriented Research Career Development Award (K23) provide support for a period of supervised study and research for clinically trained professionals who have the potential to develop into productive clinical investigators.

SBIR and STTR Phase I grants (of approximately 6-months to 2 years in duration) are to establish the technical merit and feasibility of a proposed research effort that may lead to a commercial product or process.

Phase II grants (of approximately 1 to 3 years in duration) are for the continuation of the research efforts initiated in Phase I that are likely to result in commercial products or processes.

Phase II funding is based on results of research initiated in Phase I, scientific and technical merit, and commercial potential of Phase II application.

Grant funds may be expended only for the purpose stated in the application and award document.

The NINDS participates in the NIH SBIR/STTR 'fast track' and Phase IIB initiatives.

Eligibility Requirements

Applicant Eligibility

Research Grants: Any public, private, nonprofit, or for-profit institution is eligible to apply.

For-profit institutions are not eligible for Institutional National Research Service Awards but are eligible for Individual NRSAs.

All proposals are reviewed for scientific merit, for evaluation of the qualifications of the investigators, for adequacy of the research environment, and for significance of the problem.

Approved proposals compete for available funds.

All Career Development Program awardees, with the exception of awardees of the Pathway to Independence Award (K99/R00), must be citizens or have been admitted to the United States for permanent residence.

Candidates must be nominated for the program by a nonfederal public or private nonprofit institution located in the United States, its possessions or territories.

To be eligible, postdoctoral NRSA trainees or fellows must have a professional or scientific degree (M.D., Ph.D., D.D.S., D.O., D.V.M., Sc.D., D.

Eng., or equivalent domestic or foreign degree).

SBIR grants can be awarded only to domestic small businesses (entities that are independently owned and operated for profit, are not dominant in the field in which research is proposed, and have no more than 500 employees).

Primary employment (more than one-half time) of the principal investigator must be with the small business at the time of award and during the conduct of the proposed project.

In both Phase I and Phase II, the entire research must be performed in the United States.

To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council.

STTR grants can be awarded only to domestic small business concerns (entities that are independently owned and operated for profit, are not dominant in the field in which research is proposed and have no more than 500 employees) which 'partner' with a research institution in cooperative research and development.

At least 40 percent of the project is to be performed by the small business concern and at least 30 percent by the research institution.

In both Phase I and Phase II, the research must be performed in the U.S.

and its possessions.

To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council.

Beneficiary Eligibility

Health professionals, graduate students, health professional students, scientists, and researchers.

Credentials/Documentation

Research grants are awarded to an institution in the name of an individual investigator. Persons qualified to carry out research related to the extramural programs described above may apply for funds to support their investigations. Mentored Career Development Program training must be conducted under the direction of a competent sponsor. National Research Service Awards: individual NRSA Fellowships for postdoctoral training: the candidate's academic record, research experience, citizenship, institutional sponsorship, and the proposed area and plan of training must be included in the application. Institutional Training Grants for predoctoral and postdoctoral training: the applicant institution must show the objectives, methodology and resources for the research training program; the qualifications and experience of directing staff; the criteria to be used in selecting individuals for stipend support; and a detailed budget and justification for the amount of grant funds requested. For-profit organizations' costs are determined in accordance with Subpart 31.2 of the Federal Acquisition Regulations. For other grantees, costs will be determined in accordance with HHS Regulations 45 CFR 75. For SBIR and STTR grants, the applicant organization (small business concern) must present in a research plan an idea that has potential for commercialization and furnish evidence that scientific competence, experimental methods, facilities, equipment, and funds requested are appropriate to carry out the plan. 2 CFR 200, Subpart E - Cost Principles applies to this program.

Aplication and Award Process

Preapplication Coordination

Research grant applications that request $500,000 or more in direct costs in any yearly budget period will not be accepted unless the NINDS has agreed to accept the application prior to submission (see http://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-004.html).

Environmental impact information is not required for this program.

This program is excluded from coverage under E.O.

12372.

Application Procedures

2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. 45 CFR 75 applies to this program. NIH has transitioned to the SF424 family of forms and electronic submission through Grants.gov for most research programs and funding mechanisms. All applications must be submitted in response to a specific funding opportunity announcement (FOA). The FOA will specify which forms should be used for submission.

Award Procedures

Research Grant and Training Program applications are reviewed initially by technical panels, composed of scientific authorities, and by the National Advisory Neurological Disorders and Stroke Council composed of 18 leaders in medical science, education, and public affairs. Approved applications will compete on a merit basis for available funds. Formal award notices are transmitted to the grantee or awardee. All accepted SBIR/STTR applications are evaluated for scientific and technical merit by an appropriate scientific peer review panel and by a national advisory council or board. All applications receiving a priority score compete for available SBIR/STTR set-aside funds on the basis of scientific and technical merit and commercial potential of the proposed research, program relevance, and program balance among the areas of research.

Deadlines

Contact the headquarters or regional office, as appropriate, for application deadlines.

Authorization

Public Health Service Act, Sections 301, 405,408, 457, 458, 459, and 487, Public Law 78-410, 42 U.S.C 241-285L-2; Small Business Research and Development Enhancement Act of 1992, Public Law 102-564.

Range of Approval/Disapproval Time

Research grants: Approximately 6 to 9 months. Career program: From 7 to 8 months. SBIR/STTR applications: Approximately 6 to 9 months. Institutional Training Grants: From 6 to 12 months.

Appeals

A principal investigator (P.I.) may question the substantive or procedural aspects of the review of his/her application by communicating with the staff of the Institute, and subsequently, the P.I. and applicant institution may appeal to the NINDS appeals officer. A description of the NIH Peer Review Appeal procedures is available on the NIH home page http://grants.nih.gov/grants/guide/notice-files/NOT-OD-11-064.html.

Renewals

By application and review in same manner as new applications. A P.I. should consult the specific FOA to determine if a particular grant is renewable.

Assistance Considerations

Formula and Matching Requirements

This program has no statutory formula. Matching requirements are not applicable to this program. MOE requirements are not applicable to this program.

Length and Time Phasing of Assistance

Research grant awards are made for a 12-month period with recommendation of up to 4 years of additional support. Career Program awards provide support for 3 to 5 years. Training Program awards are usually for a 12-month period with recommendation of additional support of up to a total of 5 years for predoctoral training and no more than 3 years for postdoctoral training. SBIR: Normally, Phase I awards are for 6 months; normally, Phase II awards are for 2 years. STTR: Normally, Phase I awards are for 1 year; normally, Phase II awards are for 2 years. Method of awarding/releasing assistance: quarterly. Method of awarding/releasing assistance: quarterly.

Post Assistance Requirements

Reports

Research Grants: annual and final progress reports, including a description of results, positive and negative, and a list of any publications.

Career Development Program: awardee submits annual progress report.

Termination notice, PHS 416-7, must be submitted upon completion of NRSA training.

Reports are required after termination of National Research Service Awards to ascertain compliance with the service and payback provisions.

A Financial Status Report must be submitted within 90 days after the close of each budget period for which an award has been issued.

No cash reports are required.

No expenditure reports are required.

No performance monitoring is required.

Research Grants: annual and final progress reports, including a description of results, positive and negative, and a list of any publications.

Career Program: Awardee submits annual progress report.

Termination notice, PHS 416-7, must be submitted upon completion of NRSA training.

Reports are required after termination of National Research Service Awards to ascertain compliance with the service and payback provisions.

A Financial Status Report must be submitted within 90 days after the close of each budget period for which an award has been issued.

No expenditure reports are required.

No performance monitoring is required.

No cash reports are required.

Research Grants: Annual and final progress reports, including a description of results, positive and negative, and a list of any publications.

No cash reports are required.

Research Grants: Annual and final progress reports, including a description of results, positive and negative, and a list of any publications.

Career Program: Awardee submits annual progress report.

Termination notice, PHS 416-7, must be submitted upon completion of NRSA training.

Reports are required after termination of National Research Service Awards to ascertain compliance with the service and payback provisions.

A Financial Status Report must be submitted within 90 days after the close of each budget period for which an award has been issued.

No expenditure reports are required.

No performance monitoring is required.

Audits

In accordance with the provisions of 2 CFR 200, Subpart F - Audit Requirements, non-Federal entities that expend financial assistance of $750,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Non-Federal entities that expend less than $750,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in 2 CFR 200.503. In accordance with the provisions of 45 CFR 75 nonfederal entities that expend financial assistance of $750,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Nonfederal entities that expend less than $750,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in 45 CFR 75 . Records must be available for review or audit by appropriate officials of the Federal agency, pass-through entity, and Government Accountability Office (GAO). In accordance with 45 CFR 75 , for-profit (commercial) organizations are subject to audit requirements for a non-Federal audit if, during its fiscal year, it expended $750,000 or more under HHS awards and at least one award is a HHS grant or subgrant. The regulation incorporates the thresholds and deadlines of 45 CFR 75 , but provides for profit organizations with two options for the type of audit that will satisfy the audit requirement: 1. a financial related audit of the HHS awards in accordance with Government Auditing Standards, or 2. an audit that meets the requirements of 45 CFR 75 . In accordance with ?NIH? Grants Policy Statement, Foreign grantees are subject to the same audit requirements as for-profit (commercial) organizations.

Records

Grantees generally must retain financial and programmatic records, supporting documents, statistical records, and all other records that are required by the terms of a grant, or may reasonably be considered pertinent to a grant, for a period of 3 years from the date the annual FSR is submitted. For awards under SNAP (other than those to foreign organizations and Federal institutions), the 3-year retention period will be calculated from the date the FSR for the entire competitive segment is submitted. Those grantees must retain the records pertinent to the entire competitive segment for 3 years from the date the FSR is submitted to NIH. Foreign organizations and Federal institutions must retain records for 3 years from the date of submission of the annual FSR to NIH. See 45 CFR 75 for exceptions and qualifications to the 3-year retention requirement (e.g., if any litigation, claim, financial management review, or audit is started before the expiration of the 3-year period, the records must be retained until all litigation, claims, or audit findings involving the records have been resolved and final action taken). Those sections also specify the retention period for other types of grant-related records, including F&A cost proposals and property records. See 45 CFR 75 for record retention and access requirements for contracts under grants. In accordance with 45 CFR 75 of Federal Regulations, the HHS Inspector General, the U.S. Comptroller General, or any of their duly authorized representatives have the right of timely and unrestricted access to any books, documents, papers, or other records of recipients that are pertinent to awards in order to make audits, examinations, excerpts, transcripts, and copies of such documents. This right also includes timely and reasonable access to a recipient?s personnel records for the purpose of interview and discussion related to such documents. The rights of access are not limited to the required retention period, but shall last as long as records are retained.

Financial Information

Account Identification

75-0886-0-1-552 - Extramural Research.

Obigations

(Project Grants) FY 16 $1,216,538,446; FY 17 est $1,290,920,000; and FY 18 est $901,281,223. (Project Grants (Contracts)) FY 16 $80,749,958; FY 17 est $76,581,000; and FY 18 est $74,209,419

Range and Average of Financial Assistance

Research grants: $9,219 to $6,297,501; $401,755. National Research Service Awards: Institutional $46,245 to $470,547; $209,407. Individual: $5,467 to $66,354; $42,241. SBIR/STTR: Phase 1 not to exceed $150,000; Phase II not to exceed $1,000,000; however with appropriate justification, budget caps for Phase I and Phase II are $225,000 and $1,500,00 respectively.

Regulations, Guidelines, and Literature

45 CFR 75 ; Grants will be available under the authority of and administered in accordance with the ?NIH? Grants Policy Statement and Federal regulations at . 45 CFR 75 and 42 USC 241; Omnibus Solicitation of the Public Health Service for Small Business Innovation Research (SBIR) Grant and Cooperative Agreement Applications. Omnibus Solicitation of the National Institutes of Health for Small Business Technology Transfer (STTR) Grant Applications.

Information Contacts

Regional or Local Office

None. National Institute of Neurological Disorders and Stroke (NINDS), Division of Extramural Research (DER), National Institutes of Health, Department of Health and Human Services, Neuroscience Center, 6001 Executive Boulevard, Bethesda, MD 20892. Director DER: Dr. Robert Finkelstein, Suite 3309, Telephone: (301) 496- 9248. The address above (include suite #'s below) should be used for each Program Contact: Dr. Patrick Bellgowan, Repair and Plasticity, Suite 2205, Telephone: (301) 496-1447; Dr. Francesca Bosetti, Neural Environment, Suite 2115, Telephone: (301) 496-1431; Dr. Beth-Anne Sieber, Neurodegeneration, Suite 2223, Telephone: (301) 496-5680; Dr. Janet He, Systems & Cognitive Neuroscience, Suite 2227, telephone: (301) 496-9964; Dr. Vicky Whittemore, Channels, Synapses & Circuits, Suite 2133, Telephone: (301) 496-1917; Dr. Robert Riddle, Neurogenetics, Suite 2156, Telephone: (301) 496-5745; Dr. Claudia Moy, Office of International Activities, Suite 2214, Telephone: 301-496-9135; Dr. Elizabeth McNeil, Office of Clinical Research, Suite 2213, Telephone: (301) 496-9135; Dr. Alan Willard, Office of Translational Research, Suite 3279, Telephone: (301) 496-9746; Grants Management Branch: Ms. Tijuanna DeCoster, Grants Management Officer, Suite 3258, Telephone: (301) 496-9231; Contracts Management Branch: Mr. Kirk Davis, Contracts Management Officer, Suite 3280, Telephone: (301) 496-1813; Dr. Stephen Korn, Office of Training, Career Development, and Workforce Diversity Officer, Suite 2186, Telephone: (301) 496-4188.

Headquarters Office

Robert F. Finkelstein, 6001 Executive Boulevard, Suite 3309, Rockville, Maryland 20892 Email: finkelsR@nih.gov Phone: (301) 496-9248 Fax: (301) 402-4370.

Criteria for Selecting Proposals

The major elements in evaluating proposals include assessments of: (1) the scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) the soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) the degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific and technical merit of the proposed approach for achieving the Phase II objectives; (3) the qualifications of the proposed principal investigator, supporting staff, and consultants; (4) the technological innovation, originality, or societal importance of the proposed research; (5) the potential of the proposed research for commercial application; (6) the reasonableness of the budget requested for the work proposed; (7) the adequacy and suitability of the facilities and research environment; and 8) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment.



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