The National Institute of General Medical Sciences (NIGMS) supports basic research that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment and prevention.

NIGMS-funded scientists investigate how living systems work at a range of

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levels, from molecules and cells to tissues, whole organisms and populations.

The Institute also supports research in certain clinical areas, primarily those that affect multiple organ systems.

To assure the vitality and continued productivity of the research enterprise, NIGMS provides leadership in training the next generation of scientists, in enhancing the diversity of the scientific workforce, and in developing research capacities throughout the country.

Selected Recipients for this Program

Not Applicable.

Uses and Use Restrictions

NIGMS is organized into divisions and a center that support research and research training in a range of scientific fields.

Major areas in which these units fund research are listed below their names: Division of Biomedical Technology, Bioinformatics, and Computational Biology Biomedical technology and software development Cell and molecular modeling and simulation Computational genomics and bioinformatics Database design and enhancement High-throughput data analysis Division of Cell Biology and Biophysics Analytical and separation techniques Biophysical properties of proteins and nucleic acids Cell organization, motility and division Cellular imaging Membrane structure and function Molecular biophysics Protein folding and dynamics Proteomics Single-molecule biophysics and nanoscience Spectroscopic techniques Structural biology Division of Genetics and Developmental Biology Chromosomes and epigenetics Developmental biology and genetics DNA replication, recombination and repair Genetic basis of human biology Neurogenetics and the genetics of behavior Non-coding RNAs Population genetics, evolution and the genetics of complex traits Protein synthesis Regulation of cell growth, cell cycle, cell death and differentiation Regulation of cellular processes by signaling Stem cell biology Transcription and RNA processing Division of Pharmacology, Physiology, and Biological Chemistry Anesthesiology and peri-operative pain Bioenergetics and mitochondrial physiology Bioinorganic chemistry Biotechnology Chemical biology Chemical synthesis Clinical pharmacology Drug metabolism and transporters Enzymology and enzyme mechanisms Glycosciences Molecular immunobiology Pharmacology, including signal transduction Redox biochemistry and oxidative stress Sepsis Synthetic biology and natural products Trauma, burn injury and wound healing Division of Training, Workforce Development, and Diversity Undergraduate student training and development Postbaccalaureate research education Predoctoral research training Postdoctoral research training, career development and transition to independence Workforce development research Center for Research Capacity Building Undergraduate research experiences and student development Junior faculty research development and mentoring Basic, clinical and translational biomedical research, including on conditions that disproportionately affect medically underserved populations The formation of collaborative research and training networks The enhancement of biomedical research infrastructure and of access to shared research resources Innovative educational programs designed to improve life science literacy throughout the nation.

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Eligibility Requirements

Applicant Eligibility

NIGMS trainees must be U.S.

citizens, non-citizen nationals or permanent residents.

Beneficiary Eligibility

Any nonprofit or for-profit organization, company or institution engaged in biomedical research.

Credentials/Documentation

Each applicant for research projects must present a research plan and furnish evidence that scientific competence, facilities, equipment and supplies are appropriate to carry out the plan. 2 CFR 200, Subpart E - Cost Principles applies to this program.

Aplication and Award Process

Preapplication Coordination

Preapplication coordination is not applicable.

Environmental impact information is not required for this program.

This program is excluded from coverage under E.O.

12372.

Application Procedures

This program is excluded from coverage under 2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards. NIH announces availability of funds for grant programs by issuing funding opportunity announcements in the NIH Guide for Grants and Contracts (https://grants.nih.gov/grants/guide) and on Grants.gov (https://www.grants.gov). Application packages must be downloaded from Grants.gov and the majority must be submitted through Grants.gov. This program is subject to the provisions of 45 CFR, Part 92 for state and local governments and 45 CFR, Part 72 for other organizations, as appropriate.

Award Procedures

All accepted applications are reviewed for scientific merit by an appropriate initial review group and by a national advisory council. National Research Service Award (NRSA) applications for the support of individual fellows and other applications requesting less than $50,000 direct costs per year are not reviewed by the council. All approved applications compete for available funds on the basis of scientific merit and program emphasis.

Deadlines

Contact the headquarters or regional office, as appropriate, for application deadlines.

Authorization

Section 301 and Title IV of the Public Health Service Act, as amended.

Range of Approval/Disapproval Time

Project Grants: about 9 months. NRSA: (institutional) 9-12 months, (individual) 6 months. Small Business Innovation Research (SBIR)/Small Business Technology Transfer Research (STTR): about 7-1/2 months.

Appeals

A principal investigator may question the substantive or procedural aspects of the review of his/her application by communicating with the staff of the Institute. A description of the NIH Peer Review Appeal procedures is available on the NIH website at https://grants.nih.gov/grants/guide/notice-files/NOT-OD-11-064.html.

Renewals

Renewal grants are generally made prior to the expiration of any current award.

Assistance Considerations

Formula and Matching Requirements

This program has no statutory formula. Matching requirements are not applicable to this program. MOE requirements are not applicable to this program.

Length and Time Phasing of Assistance

Almost all awards are made for at least 1 year, with additional support (up to 4 more years) depending on the recommendation of the scientific review group, the national advisory council, successful annual performance and availability of funds. See the following for information on how assistance is awarded/released: varies by program, always on an annual basis.

Post Assistance Requirements

Reports

Varies by program, always on an annual basis.

Varies by program, always on an annual basis.

Varies by program, always on an annual basis.

Varies by program, always on an annual basis.

Varies by program, always on an annual basis.

Audits

In accordance with the provisions of 2 CFR 200, Subpart F - Audit Requirements, non-Federal entities that expend financial assistance of $750,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Non-Federal entities that expend less than $750,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in 2 CFR 200.503. Audits of profit making organizations are addressed in 45 CFR Part 72 (Subpart C, Section 74.26). In addition, grants and cooperative agreements are subject to inspection and audits by DHHS and other federal government officials.

Records

Expenditures and other financial records must be retained for 3 years from the day on which the grantee submits the last financial status report for the report period.

Financial Information

Account Identification

75-0897-0-1-552.

Obigations

(Project Grants) FY 16 $2,411,311,000; FY 17 est $2,543,507,000; and FY 18 est $2,099,702,000

Range and Average of Financial Assistance

$20,000 to $10,000,000.

Regulations, Guidelines, and Literature

45 CFR 16 Procedures of the Departmental Grant Appeals Board; 45 CFR 74; 45 CFR 92; NIH Extramural Programs brochure; miscellaneous program literature from headquarters office. Grants will be available under the authority of and administered in accordance with the NIH Grants Policy Statement and federal regulations at 42 CFR 52 and 42 USC 241; Omnibus Solicitation of the Public Health Service for Small Business Innovation Research (SBIR) Grant and Cooperative Agreement Applications; and Omnibus Solicitation of the National Institutes of Health for Small Business Technology Transfer (STTR) Grant Applications.

Information Contacts

Regional or Local Office

None.

Headquarters Office

Susan J. Athey 45 Center Drive MSC6200, Bethesda, Maryland 20892 Email: atheys@nigms.nih.gov Phone: (301) 496-7301 Fax: (301) 402-0224

Criteria for Selecting Proposals

For an overview of NIGMS grant application and review, including funding policy, see https://www.nigms.nih.gov/research/application/pages/grantapprev.aspx. For more information about NIGMS, visit https://www.nigms.nih.gov.