Medical Library Assistance

To meet a growing need for investigators trained in biomedical informatics research and data science by training qualified pre- and post-doctoral candidates; to conduct research in biomedical informatics, bioinformatics and related computer, information and data sciences; to facilitate management of

credit: Active Rain
electronic health records and clinical research data; to prepare scholarly works in biomedicine and health; to advance biocomputing and bioinformatics through participation in Federal initiatives relating to biomedical informatics, bioinformatics and biomedical computing; and to stimulate and foster scientific and technological innovation through cooperative research development carried out between small business concerns and research institutions, through Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grants.
Examples of Funded Projects

Fiscal Year 2016: An ongoing list of NLM-awarded grants may be found at http://www.nlm.nih/gov/Awards2016.html.

Fiscal Year 2017: An ongoing list of NLM-awarded grants may be found at http://www.nlm.nih/gov/Awards2017.html.

Fiscal Year 2018: No current data available.

Agency - Department of Health and Human Services

The Department of Health and Human Services is the Federal government's principal agency for protecting the health of all Americans and providing essential human services, especially to those who are least able to help themselves.

Relevant Nonprofit Program Categories

Selected Recipients for this Program

RecipientAmount Start DateEnd Date
University Of Pittsburgh, The $ 136,323   2022-09-152027-08-31
Wake Forest University Health Sciences $ 134,997   2022-09-152027-08-31
Oregon Health & Science University $ 136,023   2022-09-152027-08-31
Ohio State University, The $ 121,953   2022-09-152027-08-31
The University Of Texas At Arlington $ 135,000   2022-09-152027-08-31
Washington University, The $ 134,922   2022-09-152027-08-31
University Of Arizona $ 114,381   2022-09-152027-08-31
Fred Hutchinson Cancer Center $ 134,454   2022-09-152027-08-31
Meharry Medical College $ 139,000   2022-09-152027-08-31
Trustees Of Indiana University $ 135,000   2022-09-152027-08-31

Program Accomplishments

Fiscal Year 2016: NLM received over 270 competing applications; of those 229 were reviewed and 47 awards were issued. NLM funded 101 noncompeting renewal applications. A total of 148 new and continuing awards were issued. The overall success rate was 13.5%. Fiscal Year 2017: 320 new and continuing applications will be received. 130 new and continuing awards will be made. Fiscal Year 2018: 320 new and continuing applications will be received. 130 new and continuing awards will be made.

Uses and Use Restrictions

RESEARCH GRANT PROGRAMS: Research Grants are available for fundamental and applied research in biomedical informatics and bioinformatics.

Areas of research interest include: representation, organization and retrieval of biomedical and biological knowledge, data and images; enhancement of human intellectual capacities through virtual reality, dynamic modeling, artificial intelligence, and machine learning; medical decision-making; linguistic analyses for natural language processing and understanding; informatics topics relevant to public health, consumer information and disaster information management.

Research Project Grants (R01) are available for rigorous scientific research studies and experiments.

From time to time, NLM issues Requests for Applications for innovative informatics research in special priority areas.

Exploratory/Developmental Grants (R21) support early, conceptual work and feasibility tests.

Other research grants include Informatics Conference Grants (R13) and several NIH-wide grant programs on high priority topics such as health literacy, behavioral research, health disparity, climate change, and detection of gene environment interactions for complex human diseases.

Further information on research grants is available at TRAINING GRANT PROGRAMS: NLM's University-based Biomedical Informatics Research Training Programs (T15) promote the training of talented individuals who seek research careers in biomedical informatics, translational bioinformatics, clinical research informatics, public health informatics and data science.

A competition for these institution-based training grants is announced every five years.

The most recent competition was held in 2016.

University-based training support may be at the pre- or post-doctoral level.

Training sites recruit and choose their trainees, and are expected to have well-established computing resources, strong informatics research and education programs, experienced faculty and staff committed to research in the field of biomedical informatics and/or biomedical computing, and available courses or experience in biomedical informatics, information science, and cognitive sciences.

Institutional training grants provide trainee stipends, tuition and fees, travel, and certain institutional support costs.

Further information on training grants is available at CAREER DEVELOPMENT GRANT PROGRAMS: NLM offers a Career Development award (K01) to help promising junior investigators launch their research careers in biomedical informatics and data science research.

NIH Pathway to Independence awards (K99/R00) are reserved for investigators who are making the transition to their first research positions.

These grants can last up to five years.

They include a mentored period, followed by an unmentored period, and provide both salary and a research support.

Research supplement awards are also offered to promote diversity in health-related informatics and data science research, and to promote re-entry into informatics and data science careers.

Diversity and re-entry awards are issued as supplements to existing research grants funded by NLM.

Further information on career development grants is available at RESOURCE GRANT PROGRAMS: NLM funds cooperative agreements (UG4) to support Regional Medical Libraries (RMLs) as an integral component of the National Network of Libraries of Medicine (NN/LM).

The goal of the NN/LM is to advance the progress of medicine and improve public health by providing U. S. health professionals with equal access to biomedical information, and to improve individuals? access to information to enable them to make informed decisions about their health.

The RMLs coordinate the operation of the network of libraries and other organizations that make up the NN/LM.

NLM Information Resource Grants to Reduce Health Disparities (G08) support implementation projects that bring useful, usable health information to health disparity populations and their health care providers.

NLM offers Grants for Scholarly Works (G13) to support preparation of books in the history and philosophy of biomedicine, bioethics, and public policy areas of importance to health professionals and biomedical scientists.

The purpose, restrictions, funding periods and award limits vary for these grant programs and are described in the funding opportunity announcements (FOAs).

Further information on resource grants is available at SMALL BUSINESS RESEARCH & DEVELOPMENT GRANT PROGRAMS: Small Business Innovation Research (SBIR) and Small Business Technology Transfer Research (STTR) grants are made to U. S. small businesses that seek to undertake informatics and data science research and development leading to commercialization.

The STTR program requires a small business applicant organization to formally collaborate with a research institution in Phase I and Phase II.

SBIR Phase I grants are to establish the technical merit and feasibility of a proposed research effort that may lead to a commercial product or process.

Phase II grants are for the continuation of the research initiated in Phase I and that are likely to result in commercial products or processes.

STTR Phase I grants are to determine the scientific, technical, and commercial merit and feasibility of the proposed cooperative effort that has potential for commercial application.

Phase II funding is based on results of research initiated in Phase I, and scientific and technical merit and commercial potential of the proposed project in Phase II application.

Further information on SBIR/STTR grants is available at

Eligibility Requirements

Applicant Eligibility

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the project director/principal investigator (PD/PI) is invited to work with his/her organization to develop an application for support.

Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

See Beneficiary Eligibility below for further details.

Beneficiary Eligibility

Research Grants are available to public or private, domestic or foreign, for profit or not-for-profit institutions or organizations with research capabilities in biomedical informatics, bioinformatics, computer sciences, information sciences, data sciences and related disciplines. Training Grants may be made to nonfederal public and nonprofit private institutions. With the exception of NIH Pathway to Independence awards, trainees must be citizens or non-citizen nationals of the United States or have been lawfully admitted to the United States for permanent residence. Resource grants (Information Resource, Scholarly Works) are open to any U.S. public or private nonprofit institution or organization. SBIR and STTR grants can be awarded only to domestic small businesses (entities that are independently owned and operated for profit, are not dominant in the field in which research is proposed, and have no more than 500 employees). To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council.


This program is subject to the Uniform Guidelines (2 CFR 200), Subpart E - Cost Principles. These guidelines consolidate all cost principles, audit and administrative requirements for Federal grants and cooperative agreements. 2 CFR 200, Subpart E - Cost Principles applies to this program. 2 CFR 200, Subpart E - Cost Principles applies to this program.

Aplication and Award Process

Preapplication Coordination

Preapplication coordination is not applicable.

Environmental impact information is not required for this program.

This program is excluded from coverage under E.O.


Application Procedures

2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. 2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. Generally, electronic applications are accepted for Research & Training Grants, SBIR and STTR grants, Resource Grants as well as Fellowship awards. Electronic grant submission of the SF424 (R&R) form is via For instructions on submitting grants electronically, see These programs are subject to the provisions of 45 CFR Part 75 as applicable. Updates on NLM application deadlines and links to available forms can also be found at

Award Procedures

Research, training, career development and resource applications are evaluated for merit by a committee of scientific experts and for program relevance by the Board of Regents (BOR) of the National Library of Medicine (NLM). If favorably recommended, the applications are considered for funding. An award notice is prepared when it is determined that a grant is to be paid. All accepted SBIR/STTR applications are evaluated for scientific and technical merit by an appropriate scientific peer review panel and by a national advisory council or board. All applications receiving a priority score compete for available SBIR/STTR set-aside funds based on scientific and technical merit and commercial potential of the proposed research, program relevance, and portfolio balance among the areas of research.


Contact the headquarters or regional office, as appropriate, for application deadlines.


Public Health Service Act, Title IV, Part D, Subpart 2, Section 472-476; Public Health Service Act, Title III, Part A, Section 301.

Range of Approval/Disapproval Time

> 180 Days. From 9-10 months after the application deadline.


NIH policy allows a principal investigator (PI) to appeal the outcome of a review if procedural errors or factual errors entered into the review of the application. A description of the NIH Peer Review Appeal procedures is available at However, differences of scientific opinion that often occur between investigators and reviewers may not be contested through these procedures. In addition, communications from investigators consisting of additional information that was not available to the reviewers are not considered to be appeals. The updated NIH policy on submission of grant applications, including resubmissions, can be found at:


> 180 Days. Competing renewal applications follow the same review procedures as new applications; dates for submission are at NIH also permits the resubmission of an application that has been revised following merit review. Deadlines for resubmissions are listed with other deadlines. Applicants should consult the funding opportunity announcement to find out if renewals are allowed for that grant program.

Assistance Considerations

Formula and Matching Requirements

This program has no statutory formula. This program has no matching requirements. This program does not have MOE requirements.

Length and Time Phasing of Assistance

The length of a grant award varies by the type of grant. R01 research grants generally last three or four years. Resource grants, Exploratory/Developmental grants, and Career Transition awards have defined maximum periods that are provided in the funding opportunity announcements. See the following for information on how assistance is awarded/released: A formal notification in the form of a Notice of Award will be provided to the successful applicant organization. See the following for information on how assistance is awarded/released: A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization.

Post Assistance Requirements


No program reports are required.

No cash reports are required.

Annual progress reports submitted to NLM outline scientific progress made by the grantee within the intended specific aims and scope outlined in the competing grant application.

Mid-year progress reports may be requested by a NLM Program Officer.

At the end of a grant, the awardee must file a Final Progress Report, Final Invention statement and final Federal Financial Report.

A Federal Financial Report must be filed when requested.

A final Federal Financial Report must be filed at the end of the grant.

No performance monitoring is required.

No performance monitoring is required.


In accordance with the provisions of 2 CFR 200, Subpart F - Audit Requirements, non-Federal entities that expend financial assistance of $750,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Non-Federal entities that expend less than $750,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in 2 CFR 200.503. In accordance with the provisions of 2 CFR 200, Subpart F - Audit Requirements, non-Federal entities that expend financial assistance of $750,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Non-Federal entities that expend less than $750,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in 2 CFR 200.503. All audit requirements for this program are defined in 2 CFR 200, Subpart F - Audit Requirements.


Financial and programmatic grant records must be retained for three (3) years from the day on which the grantee submits the final Federal Financial Report (FFR). The beginning date for record retention purposes is the date of the FFR submission for the competitive segment of the grant.

Financial Information

Account Identification



(Project Grants) FY 16 $42,276,400; FY 17 est $54,254,899; and FY 18 est $54,254,899

Range and Average of Financial Assistance

$20,000 to $750,000 (range) $354,360 ? average total cost for Basic Research Grant (R01) $67,701 ? average total cost for Information Resource Grant (G08) $44,443 - average total cost for Scholarly Works Grant (G13).

Regulations, Guidelines, and Literature

National Library of Medicine Grant Programs are awarded under the Public Health Service Act and the Medical Library Assistance Act. Grants and funding awards are made available under the authority of the Acts as codified under 45 CFR 74 (Uniform Administrative Requirements for Awards and Subawards to Institutions of Higher Education, Hospitals, Other Nonprofit Organizations, and Commercial Organizations; and Certain Grants and Agreements with States, Local Governments, and Indian Tribal Governments and 45 CFR 92 (Uniform Administrative Requirements for Grants and Cooperative Agreements to States and Local Governments); the NIH Grants Policy Statement is available to grantees as a single document governing the NIH/DHHS policy requirements and terms and conditions of NIH/DHHS grant awards. Additional regulations and guidelines are provided in the Omnibus Solicitation of the Public Health Service for Small Business Innovation Research (SBIR - R43, R44) Grant and Cooperative Agreement Applications including the Omnibus Solicitation of the National Institutes of Health for Small Business Technology Transfer (STTR - R41, R42) Grant Applications.

Information Contacts

Regional or Local Office


Headquarters Office

Extramural Programs Extramural Programs National Library of Medicine, National Institutes of Health, Public Health Service, Department of Health and Human Services, Bethesda, MD 20894. Telephone: (301) 496-4621. Program Contact: Program Officer: Telephone: (301) 594-4882. Grants Management Contact: Grants Management Officer: Telephone: (301) 496-4221. Grant Review Contact: Scientific Review Officer: Telephone: (301) 496-4253. Use the same numbers for FTS. Website:, Bethesda, Maryland 20892 Phone: (301) 496-4621 , Bethesda, Maryland 20892 Phone: (301) 496-4621

Criteria for Selecting Proposals

The standard NIH review criteria, significance, investigator, innovation, approach, environment are used as the basis of merit review. Considerations for final award decisions include level of innovation, program priority, portfolio balance, and availability of funds. For NLM resource grants, review criteria include considerations as to relevance to program objectives; impact on the management and transmission of biomedical knowledge; institutional readiness and resources available to project; expertise of project director and key personnel; scientific or technical merit of project; sustainability of what is deployed, and appropriateness of budget. For Career awards, review criteria include issues pertaining to the suitability of the candidates and their career development plan, research plan, mentors/consultants/collaborators, as well as the environment and institutional commitment to the candidates. For Training awards, review criteria include evidence of soundness in the areas of: Training Program and Environment, Training Program Principal Investigator(s), Preceptors and Mentors, Trainees, and Training Record. Comparative priorities on the above criteria are based on collective judgment of peer reviewers. The following criteria are used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the scientific, technical, or technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications are reviewed based upon similar criteria, and on the degree to which the Phase I objectives were met and feasibility demonstrated.

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