Special Projects of National Significance

To quickly respond to the care and treatment needs of individuals receiving assistance under the Ryan White HIV/AIDS program (RWHAP).

Special Projects of National Significance (SPNS) supports the development and implementation of innovative delivery models of HIV care, services, and capacity
development initiatives.

Further, SPNS evaluates the effectiveness of these models, and promotes the replication of successful models.

Areas of evaluation include design, implementation, utilization, cost, and health related outcomes of effective models.

The SPNS Program also supports special programs to develop or enhance health information and technology data systems to enable RWHAP recipients and their sub-recipients or providers to report and utilize clinical data.
Related Programs

Examples of Funded Projects

Fiscal Year 2016: Fiscal Year 2016: Cooperative Agreements: Dissemination of Evidence-Informed Interventions to Improve Health Outcomes along the HIV Care Continuum Initiative - This initiative adapted four linkage and retention interventions from prior SPNS and the Secretary's Minority AIDS Initiative Fund (SMAIF) initiatives to improve health outcomes along the HIV care continuum.

The initiative is funding two cooperative agreements, a Dissemination and Evaluation Center (DEC) for five years, and an Implementation Technical Assistance Center (ITAC) for four years.

The end goal of the initiative is to produce four evidence-informed Care And Treatment Interventions (CATIs) that are replicable, cost-effective, capable of producing optimal HIV care continuum outcomes, and easily adaptable to the changing health care environment.

The multi-site evaluation of this initiative will take a rigorous Implementation Science (IS) approach, which places greater emphasis on evaluation of the implementation process and cost analyses of the interventions, while seeking to improve the HIV care continuum outcomes of linkage, retention, re-engagement and viral suppression among client participants. Grants: Use of Social Media to Improve Engagement, Retention, and Health Outcomes along the HIV Care Continuum Demonstration Sites - This initiative is a multi-site demonstration and evaluation of innovative social media methods designed to identify, link, and retain HIV positive underserved, underinsured, hard-to-reach youth and young adults (ages 13-34) in HIV primary care and supportive services.

These methods include system approaches utilizing a variety of social media, Internet, and mobile-based technologies to improve engagement and retention in care and viral suppression.

Demonstration projects are expected to implement these models, evaluate their effectiveness and to disseminate findings, best practices, and lessons learned.

These social media interventions focus on youth and young adults living with HIV who are aware of their HIV infection status but have never been engaged in care; are aware but have refused referral to care; have dropped out of care; are infected with HIV but are unaware of their HIV status; or have not achieved viral suppression.

Fiscal Year 2017: Fiscal Year 17: Improving Health Outcomes through the Coordination of Supportive Employment and Housing Services ? Demonstration Sites; Improving Health Outcomes through the Coordination of Supportive Employment and Housing Services ? Evaluation and Technical Assistance Provider; and Curing Hepatitis C among People of Color Living with HIV (SMAIF initiatives).

Fiscal Year 2018: No data available.

Agency - Department of Health and Human Services

The Department of Health and Human Services is the Federal government's principal agency for protecting the health of all Americans and providing essential human services, especially to those who are least able to help themselves.

Office - See Regional Agency Offices.
Website Address


Selected Recipients for this Program

RecipientAmount Start DateEnd Date
Corporation For Supportive Housing $ 3,500,000   2022-08-012026-07-31
Trustees Of Boston University $ 800,000   2022-08-012026-07-31
Jsi Research & Training Inc $ 1,750,000   2022-08-012025-07-31
Beth Israel Medical Center $ 299,945   2022-08-012025-07-31
Colorado Health Network, Inc. $ 245,981   2022-08-012025-07-31
Upmc Presbyterian Shadyside $ 218,093   2022-08-012025-07-31
Family Health Centers Of San Diego Inc $ 300,000   2022-08-012025-07-31
Empower U, Incorporated $ 300,000   2022-08-012025-07-31
Yale University $ 300,000   2022-08-012025-07-31
University Of Chicago $ 300,000   2022-08-012025-07-31

Program Accomplishments

Not Applicable.

Uses and Use Restrictions

Proposals are expected to adequately define and justify the needs, innovative nature, and evaluation methodology of the proposed model of services.

Funds shall be used to create and/or evaluate innovative models of HIV care, services, capacity development initiatives, and health information and technology data systems that would likely not exist nor be evaluated without SPNS Program support, or that would extend the care model to previously underserved or uninsured populations.

Funds may not be used for: charges that are billable to third party payers (e.g., private health insurance, prepaid health plans, Medicaid, Medicare); purchasing or construction of new facilities or capital improvements to existing facilities; purchasing or improving land; international travel; cash payments to intended recipients of RWHAP services; or pre-exposure prophylaxis (PrEP) or non-occupational post-exposure prophylaxis (nPEP) medications or the related medical services.

Funds may not be used for outreach programs which have HIV prevention education as their exclusive purpose, or broad-scope awareness activities about HIV services that target the general public.

Additionally, the purchase of sterile needles or syringes for the purposes of hypodermic injection of any illegal drug is not allowable.

Some aspects of syringe services programs are allowable with HRSA's prior approval and in compliance with HHS and HRSA policy (see: https://www.hiv.gov/federal-response/policies-issues/syringe-services-programs).

Eligibility Requirements

Applicant Eligibility

Academic institutions, non-profit organizations including faith-based organizations, and those eligible for funding under Parts A-D authorized by Title XXVI of the Public Health Service (PHS) Act as amended by the Ryan White HIV/AIDS Treatment Extension Act of 2009.

Additionally, federally recognized Indian Tribal Governments and tribal organizations are also eligible to apply for these funds.

Beneficiary Eligibility

Individuals living with HIV.


Applicants should review the individual HRSA notice of funding opportunity issued under this CFDA program for any required proof or certifications which must be submitted prior to or simultaneous with submission of an application package. 2 CFR 200, Subpart E - Cost Principles applies to this program.

Aplication and Award Process

Preapplication Coordination

Preapplication coordination is required.

Environmental impact information is not required for this program.

This program is eligible for coverage under E.O.

12372, 'Intergovernmental Review of Federal Programs.' An applicant should consult the office or official designated as the single point of contact in his or her State for more information on the process the State requires to be followed in applying for assistance, if the State has selected the program for review.

Application Procedures

2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. HRSA requires all applicants to apply electronically through Grants.gov.

Award Procedures

All qualified applications will be forwarded to an objective review committee. Based on the recommendations of the objective review committee, the HRSA program official with delegated authority is responsible for final selection and funding decisions. Notification is made in writing by a Notice of Award.


Contact the headquarters or regional office, as appropriate, for application deadlines.


Section 2691 of Title XXVI of the Public Health Service Act, (42 USC 300ff-101), as amended, by the Ryan White HIV/AIDS Treatment Modernization Act of 2009 (Public Law 111-87).

Range of Approval/Disapproval Time

Approximately 6 months.


Not Applicable.


Not Applicable.

Assistance Considerations

Formula and Matching Requirements

Statutory formulas are not applicable to this program. Matching requirements are not applicable to this program. MOE requirements are not applicable to this program.

Length and Time Phasing of Assistance

Grants and cooperative agreements will generally be awarded for up to a five year project period composed of up to five 12-month budget periods; some awards may have more limited 12, 24 or 36 month project periods. See the following for information on how assistance is awarded/released: Recipients draw down funds, as necessary, from the Payment Management System (PMS). PMS is the centralized web based payment system for HHS awards.

Post Assistance Requirements


Program progress reports are required.

Cash reports are not applicable.

Please refer to notice of funding opportunity and Notice of Award for any applicable program and data reports.

Recipients must submit a Federal Financial Report (FFR) or SF 425 within 120 days after the end of each budget period.

A final performance report is due within 90 days after the end of the project period.

A final Federal Financial Report must be submitted 90 days after the end of the project period.

No expenditure reports are required.

No expenditure reports are required.

No performance monitoring is required.


In accordance with the provisions of 2 CFR 200, Subpart F - Audit Requirements, non-Federal entities that expend financial assistance of $750,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Non-Federal entities that expend less than $750,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in 2 CFR 200.503.


Recipients are required to maintain financial records 3 years after the date they submit the final Federal Financial Report (FFR). If any litigation, claim, negotiation, audit or other action involving the award has been started before the expiration of the 3-year period, the records shall be retained until completion of the action and resolution of all issues which arise from it, or until the end of the regular 3-year period, whichever is later.

Financial Information

Account Identification



(Cooperative Agreements) FY 16 $6,231,128; FY 17 est $5,199,782; and FY 18 est $4,100,000. (Project Grants) FY 16 $17,098,752; FY 17 est $12,337,313; and FY 18 est $4,883,384

Range and Average of Financial Assistance

Project Grants: $263,206 to $482,500; Average $300,000; Coop. Agreements: $ 500,000 to $3,049,198. Average $550,000.

Regulations, Guidelines, and Literature

All HRSA awards are subject to the Uniform Administrative Requirements, Cost Principles, and Audit Requirements at 45 CFR part 75. HRSA awards are subject to the requirements of the HHS Grants Policy Statement (HHS GPS) that are applicable based on recipient type and purpose of award. The HHS GPS is available at http://www.hrsa.gov/grants.

Information Contacts

Regional or Local Office

See Regional Agency Offices.

Headquarters Office

Harold Phillips 5600 Fishers Lane, Room 9N-114, Rockville, Maryland 20857 Phone: (301) 443-8109

Criteria for Selecting Proposals

Evaluation criteria vary and are based on the initiative. Refer to criteria included in the notice of funding opportunity for each specific program.

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