Bench Testing Therapeutic/Indication Pairing Strategies (UG3/UH3)

This Funding Opportunity Announcement (FOA) invites applications for support of pre-clinical studies to repurpose existing experimental or FDA approved drugs or biologics (existing therapeutics) that have already begun or completed at least a Phase l trial.

The hypothesis for proposed studies


must be developed using innovative processes to identify the therapeutic/indication pair.

Examples include independent crowdsourcing strategies (e.g.,,, or any website that lists experimental therapies), or use of computational algorithms.

The initial UG3 award will support the development of milestone-driven rigorous, pre-clinical target engagement and/or efficacy studies.

Once UG3 pre-clinical milestones have been met, the UH3 award may be made to support clinical trial planning:
this includes complete planning, design, and preparation of the documentation necessary for implementation of Phase I and/or Phase II clinical trials for a new therapeutic use.
Related Programs

National Center for Advancing Translational Sciences

Department of Health and Human Services

Agency: National Institutes of Health


Estimated Funding: $1,542,548

Who's Eligible

Obtain Full Opportunity Text:

Additional Information of Eligibility:
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U. S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.

Non-domestic (non-U.S.) components of U. S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Full Opportunity Web Address:


Agency Email Description:

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