The emergent field of geroscience seeks to relate the biology of aging to the development of chronic diseases and the onset of degenerative conditions which are prevalent in the older segment of human populations.
It is generally accepted that age is the major risk factor for most chronic diseases
and degenerative conditions in adults.
Thus, a critical question in geroscience is to identify components in the biology of aging that are the underlying risk for multiple chronic diseases and degenerative conditions.
Therefore, this FOA will support planning grants to circumscribe the scope of this question and suggest ways to answer it experimentally.
The focus will be on epigenetics underlying aging as a risk factor for age-related diseases and degenerative conditions in humans.
Mortality and age-related mortality are outside the scope of this FOA.
Studies using model organisms are outside the scope of this FOA.