AHRQ Developing Prospective Practice-based Comparative Effectiveness Research Clinical Registries: Orthopedic Devices, Drugs, and Procedures (P50)

AHRQ invites applications to develop a prospective clinical registry of orthopedic devices, drugs, and procedures through a practice-based research collaborative and clinical and outcomes data resource (P50 grant mechanism).

The goal of this registry initiative is to support the development of


a sustainable data infrastructure and to conduct rigorous clinical and scientific research including comparative effectiveness and safety research.

AHRQ envisions utilizing a practice based orthopedic registry across a broad provider network as one of the potentially most effective and productive approaches to develop scientific evidence regarding the short and long term benefits and harms of implantable orthopedic devices and other related services.

The registry will be a model and basis for other national device and procedure registries and will actively disseminate study results into clinical practice.

The Medicare Prescription Drug, Improvement, and Modernization Act (MMA) Section 1013 (42 USC 299b-7)(see http://effectivehealthcare.ahrq.gov/) authorized AHRQ to develop a program of comparative effectiveness research, thus, establishing the Effective Health Care (EHC) Program.

To help achieve the objectives of the EHC program, AHRQ will provide support to develop and maintain the infrastructure of a multi-center orthopedic registry and the conduct of multiple collaborative, prospective multi-center studies of orthopedic devices and procedures.

The capacity to include community-based smaller practice sites, in addition to high volume institutions, as participants in the registry is strongly encouraged.

Related Programs

Research on Healthcare Costs, Quality and Outcomes

Department of Health and Human Services

Agency: Agency for Health Care Research and Quality


Estimated Funding: $3,000,000

Who's Eligible

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Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized).

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