Dysregulation and Proximal Risk for Suicide FOA (R01 Clinical Trial Optional)

A major goal of research on suicide is to improve our understanding of who is at most risk, why people transition from suicidal thoughts to action, and when to intervene (Prioritized Research Agenda for Suicide Prevention, Short-term Objective 1. C).

Risk is a dynamic process and suicide attempts


are often preceded by acute stressors.

While many studies of suicide risk focus on emotion dysregulation, fewer studies have examined Arousal and Regulation and how these domains dynamically shape emotional and cognitive functions such as response to reward, frustrative non-reward, cognitive flexibility and control, or decision-making.

Very few studies in the NIMH portfolio on suicide risk have focused on proximal risk.

This FOA will fund research that will address these gaps, provide understanding of the mechanisms of how dysregulation interacts with Cognition, Negative and Positive Valence to determine time-varying risk, and identify modifiable targets for timely interventions during high risk periods.

Applications submitted in response to this FOA must explicitly explore how interactions between at least one construct in the domain of Arousal and Regulation and one or more constructs in other RDoC domains are linked to imminent risk for suicide attempts.

Studies that are focused solely on static suicidal traits, past behavior, or distal risk will not be considered responsive to this FOA, nor will studies that are solely focused on a single RDoC domain.
Related Programs

Mental Health Research Grants

Department of Health and Human Services

Agency: Department of Health and Human Services

Office: National Institutes of Health

Estimated Funding: $41,000,000

Relevant Nonprofit Program Categories

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Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U. S. Territory or Possession.

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